(3R,3aR,8bS)-methyl 3a,4-dimethyl-7-nitro-3-phenyl-3,3a,4,8b-tetrahydrocyclopenta[b]indole-1-carboxylate

Base Information

• Chemical Name: (3R,3aR,8bS)-methyl 3a,4-dimethyl-7-nitro-3-phenyl-3,3a,4,8b-tetrahydrocyclopenta[b]indole-1-carboxylate
• CAS No.: 1204478-54-5
• Molecular Formula: C₂₁H₂₀N₂O₄
• Molecular Weight: 364.401
• Mol file: 1204478-54-5.mol

Synonyms:(3R,3aR,8bS)-methyl 3a,4-dimethyl-7-nitro-3-phenyl-3,3a,4,8b-tetrahydrocyclopenta[b]indole-1-carboxylate

Chemical Property of (3R,3aR,8bS)-methyl 3a,4-dimethyl-7-nitro-3-phenyl-3,3a,4,8b-tetrahydrocyclopenta[b]indole-1-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of (3R,3aR,8bS)-methyl 3a,4-dimethyl-7-nitro-3-phenyl-3,3a,4,8b-tetrahydrocyclopenta[b]indole-1-carboxylate

There total 1 articles about (3R,3aR,8bS)-methyl 3a,4-dimethyl-7-nitro-3-phenyl-3,3a,4,8b-tetrahydrocyclopenta[b]indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1,2-dimethyl-5-nitro-1H-indole (51226-47-2) + (E)-methyl 2-diazo-4-phenylbut-3-enoate (119987-21-2) → (3R,3aR,8bS)-methyl 3a,4-dimethyl-7-nitro-3-phenyl-3,3a,4,8b-tetrahydrocyclopenta[b]indole-1-carboxylate (1204478-54-5)

Guidance literature:

With Rh₂[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4; In toluene; at -20 - 20 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja9078094

upstream raw materials:

1,2-dimethyl-5-nitro-1H-indole

(E)-methyl 2-diazo-4-phenylbut-3-enoate

Refernces