N-[(1'R)-2'-hydroxy-1'-phenylethyl]-(2S)-2-amino-3-methyl-3-(1-methylindol-3-yl)butyramide

Base Information

Chemical Name:N-[(1'R)-2'-hydroxy-1'-phenylethyl]-(2S)-2-amino-3-methyl-3-(1-methylindol-3-yl)butyramide
CAS No.:377779-93-6
Molecular Formula:C₂₂H₂₇N₃O₂
Molecular Weight:365.475
Hs Code.:

Synonyms:N-[(1'R)-2'-hydroxy-1'-phenylethyl]-(2S)-2-amino-3-methyl-3-(1-methylindol-3-yl)butyramide

Suppliers and Price of N-[(1'R)-2'-hydroxy-1'-phenylethyl]-(2S)-2-amino-3-methyl-3-(1-methylindol-3-yl)butyramide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(1'R)-2'-hydroxy-1'-phenylethyl]-(2S)-2-amino-3-methyl-3-(1-methylindol-3-yl)butyramide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(1'R)-2'-hydroxy-1'-phenylethyl]-(2S)-2-amino-3-methyl-3-(1-methylindol-3-yl)butyramide

There total 6 articles about N-[(1'R)-2'-hydroxy-1'-phenylethyl]-(2S)-2-amino-3-methyl-3-(1-methylindol-3-yl)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 377779-91-4
(2S)-2-{[(1R)-2-hydroxy-1-phenylethyl]amino}-3-methyl-3-(1-methyl-1H-indole-3-yl)butanenitrile

: 377779-93-6
N-[(1'R)-2'-hydroxy-1'-phenylethyl]-(2S)-2-amino-3-methyl-3-(1-methylindol-3-yl)butyramide

Guidance literature:: With dihydrogen peroxide; potassium carbonate; dimethyl sulfoxide; In methanol; at 45 ℃; for 6h;
DOI:10.1021/jo0104882

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 377779-93-6
N-[(1'R)-2'-hydroxy-1'-phenylethyl]-(2S)-2-amino-3-methyl-3-(1-methylindol-3-yl)butyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Sc(OTf)3 / CH₂Cl₂ / 1 h / 20 °C

1.2: 81 percent / CH₂Cl₂ / 0 - 20 °C

2.1: 72 percent / K₂CO₃; DMSO; aq. H₂O₂ / methanol / 6 h / 45 °C

With dihydrogen peroxide; potassium carbonate; dimethyl sulfoxide; scandium tris(trifluoromethanesulfonate); In methanol; dichloromethane;
DOI:10.1021/jo0104882

Reference yield:

: 72228-40-1
(±)-methyl 2-(1-methyl-1H-indol-3-yl)propanoate

: 377779-93-6
N-[(1'R)-2'-hydroxy-1'-phenylethyl]-(2S)-2-amino-3-methyl-3-(1-methylindol-3-yl)butyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 - 0 °C / Inert atmosphere

1.2: 3 h / -78 - 0 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; hexane; diethyl ether / 1 h / -78 - 0 °C / Inert atmosphere

3.1: 4-methylmorpholine N-oxide / dichloromethane / 1 h / 25 °C / Molecular sieve

4.1: toluene / 1.5 h / Reflux; Inert atmosphere; Dean-Stark

4.2: 96 h / 0 - 25 °C / Inert atmosphere

5.1: potassium carbonate; dihydrogen peroxide / water; methanol; dimethyl sulfoxide / 1.5 h / 0 - 45 °C

With dihydrogen peroxide; potassium hexamethylsilazane; diisobutylaluminium hydride; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; dimethyl sulfoxide; toluene;