C₄₆H₅₀BrN₅O₉S₂Si

Base Information

Chemical Name:C₄₆H₅₀BrN₅O₉S₂Si
CAS No.:756893-90-0
Molecular Formula:C₄₆H₅₀BrN₅O₉S₂Si
Molecular Weight:989.053
Hs Code.:

C<sub>46</sub>H<sub>50</sub>BrN<sub>5</sub>O<sub>9</sub>S<sub>2</sub>Si

Synonyms:C₄₆H₅₀BrN₅O₉S₂Si

Suppliers and Price of C₄₆H₅₀BrN₅O₉S₂Si

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₄₆H₅₀BrN₅O₉S₂Si

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of C₄₆H₅₀BrN₅O₉S₂Si

There total 25 articles about C₄₆H₅₀BrN₅O₉S₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 665-27-0
1,5-quinide

: 756893-90-0
C₄₆H₅₀BrN₅O₉S₂Si

Guidance literature:: Multi-step reaction with 19 steps

1: triethylamine; DMAP / dimethylformamide / 23 °C

2: pyridinium dichromate; Celite; molecular sieves 4 Angstroem / acetonitrile / 45 °C

3: t-BuOK / tetrahydrofuran / 65 °C

4: 74 percent / molecular sieves 4 Angstroem / 5.5 h / 23 °C

5: 98 percent / triethylamine; DMAP / CH₂Cl₂ / 0.17 h / 23 °C

6: 89 percent / Pd(P(t-Bu)3)2; N-methylmorpholine N-oxide; triethylsilane / tetrahydrofuran / 3.5 h / 70 °C

7: 99 percent / H₂ / Pd/C / methanol / 7 h / 0 °C / 760 Torr

8: 93 percent / 1,1'-carbonyldiimidazole / CH₂Cl₂ / 23 °C

9: 71 percent / tetrahydrofuran / -78 - 0 °C

10: 74 percent / Pd(OAc)2; DMSO / 2-methyl-propan-2-ol; acetic acid / 10 h / 60 °C

11: H₂ / Pd/C / ethyl acetate / 0.5 h / 23 °C

12: NaH / tetrahydrofuran / 1 h / 23 °C

13: N-bromosuccinimide / 0.25 h / 0 - 23 °C

14: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

15: 77 percent / Pd(PPh₃)4; aq. Na₂CO₃; benzene / methanol / 65 h / 50 °C

16: aq. LiBF₄ / acetonitrile / 30 h / 45 - 50 °C

17: Dess-Martin periodinane / CH₂Cl₂ / 0.05 h / 23 °C

18: NH₂OH*HCl; aq. NaOAc / methanol / 3.5 h / 23 °C

19: Bu₄NBr; aq. KOH / toluene / 1.5 h / 0 °C

With triethylsilane; dmap; palladium diacetate; potassium hydroxide; N-Bromosuccinimide; dipyridinium dichromate; lithium tetrafluoroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 4 A molecular sieve; Celite; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutylammomium bromide; hydrogen; sodium acetate; sodium hydride; sodium carbonate; Dess-Martin periodane; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; 1,1'-carbonyldiimidazole; benzene; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol; 3: Wittig olefination / 10: intramolecular Heck cyclization / 15: Suzuki coupling;
DOI:10.1021/ja050586v

Reference yield:

: 77-95-2
D-(-)-quinic acid

: 756893-90-0
C₄₆H₅₀BrN₅O₉S₂Si

Guidance literature:: Multi-step reaction with 20 steps

1: Amberlyst H⁺ resin; benzene / dimethylformamide / Heating

2: triethylamine; DMAP / dimethylformamide / 23 °C

3: pyridinium dichromate; Celite; molecular sieves 4 Angstroem / acetonitrile / 45 °C

4: t-BuOK / tetrahydrofuran / 65 °C

5: 74 percent / molecular sieves 4 Angstroem / 5.5 h / 23 °C

6: 98 percent / triethylamine; DMAP / CH₂Cl₂ / 0.17 h / 23 °C

7: 89 percent / Pd(P(t-Bu)3)2; N-methylmorpholine N-oxide; triethylsilane / tetrahydrofuran / 3.5 h / 70 °C

8: 99 percent / H₂ / Pd/C / methanol / 7 h / 0 °C / 760 Torr

9: 93 percent / 1,1'-carbonyldiimidazole / CH₂Cl₂ / 23 °C

10: 71 percent / tetrahydrofuran / -78 - 0 °C

11: 74 percent / Pd(OAc)2; DMSO / 2-methyl-propan-2-ol; acetic acid / 10 h / 60 °C

12: H₂ / Pd/C / ethyl acetate / 0.5 h / 23 °C

13: NaH / tetrahydrofuran / 1 h / 23 °C

14: N-bromosuccinimide / 0.25 h / 0 - 23 °C

15: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

16: 77 percent / Pd(PPh₃)4; aq. Na₂CO₃; benzene / methanol / 65 h / 50 °C

17: aq. LiBF₄ / acetonitrile / 30 h / 45 - 50 °C

18: Dess-Martin periodinane / CH₂Cl₂ / 0.05 h / 23 °C

19: NH₂OH*HCl; aq. NaOAc / methanol / 3.5 h / 23 °C

20: Bu₄NBr; aq. KOH / toluene / 1.5 h / 0 °C

With triethylsilane; dmap; palladium diacetate; potassium hydroxide; N-Bromosuccinimide; dipyridinium dichromate; lithium tetrafluoroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 4 A molecular sieve; Amberlyst H⁺ resin; Celite; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutylammomium bromide; hydrogen; sodium acetate; sodium hydride; sodium carbonate; Dess-Martin periodane; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; 1,1'-carbonyldiimidazole; benzene; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol; 4: Wittig olefination / 11: intramolecular Heck cyclization / 16: Suzuki coupling;
DOI:10.1021/ja050586v

Reference yield:

: 766529-94-6
(1R,3R,5R)-3-[(tert-butyldimethylsilyl)oxy]-1-hydroxy-6-oxa-bicyclo[3.2.1]octane-4,7-dione

: 756893-90-0
C₄₆H₅₀BrN₅O₉S₂Si

Guidance literature:: Multi-step reaction with 17 steps

1: t-BuOK / tetrahydrofuran / 65 °C

2: 74 percent / molecular sieves 4 Angstroem / 5.5 h / 23 °C

3: 98 percent / triethylamine; DMAP / CH₂Cl₂ / 0.17 h / 23 °C

4: 89 percent / Pd(P(t-Bu)3)2; N-methylmorpholine N-oxide; triethylsilane / tetrahydrofuran / 3.5 h / 70 °C

5: 99 percent / H₂ / Pd/C / methanol / 7 h / 0 °C / 760 Torr

6: 93 percent / 1,1'-carbonyldiimidazole / CH₂Cl₂ / 23 °C

7: 71 percent / tetrahydrofuran / -78 - 0 °C

8: 74 percent / Pd(OAc)2; DMSO / 2-methyl-propan-2-ol; acetic acid / 10 h / 60 °C

9: H₂ / Pd/C / ethyl acetate / 0.5 h / 23 °C

10: NaH / tetrahydrofuran / 1 h / 23 °C

11: N-bromosuccinimide / 0.25 h / 0 - 23 °C

12: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

13: 77 percent / Pd(PPh₃)4; aq. Na₂CO₃; benzene / methanol / 65 h / 50 °C

14: aq. LiBF₄ / acetonitrile / 30 h / 45 - 50 °C

15: Dess-Martin periodinane / CH₂Cl₂ / 0.05 h / 23 °C

16: NH₂OH*HCl; aq. NaOAc / methanol / 3.5 h / 23 °C

17: Bu₄NBr; aq. KOH / toluene / 1.5 h / 0 °C

With triethylsilane; dmap; palladium diacetate; potassium hydroxide; N-Bromosuccinimide; lithium tetrafluoroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 4 A molecular sieve; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutylammomium bromide; hydrogen; sodium acetate; sodium hydride; sodium carbonate; Dess-Martin periodane; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; 1,1'-carbonyldiimidazole; benzene; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol; 1: Wittig olefination / 8: intramolecular Heck cyclization / 13: Suzuki coupling;
DOI:10.1021/ja050586v