2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-(4-fluorophenyl)thiophen-2-yl]isoindoline-1,3-dione

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Chemical Name:2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-(4-fluorophenyl)thiophen-2-yl]isoindoline-1,3-dione
CAS No.:1394868-09-7
Molecular Formula:C₂₆H₁₄BrClFNO₃S
Molecular Weight:554.823
Hs Code.:

Synonyms:2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-(4-fluorophenyl)thiophen-2-yl]isoindoline-1,3-dione

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Chemical Property of 2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-(4-fluorophenyl)thiophen-2-yl]isoindoline-1,3-dione

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Technology Process of 2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-(4-fluorophenyl)thiophen-2-yl]isoindoline-1,3-dione

There total 3 articles about 2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-(4-fluorophenyl)thiophen-2-yl]isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1394868-07-5
2-[3-(4-chlorobenzoyl)-5-(4-fluorophenyl)-4-methylthiophen-2-yl]isoindoline-1,3-dione

: 1394868-09-7
2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-(4-fluorophenyl)thiophen-2-yl]isoindoline-1,3-dione

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In 1,2-dichloro-ethane; for 3h; Inert atmosphere; Reflux;
DOI:10.1021/jm3007504

Reference yield:

: 1027493-29-3
2-[5-bromo-3-(4-chloro-benzoyl)-4-methyl-thiophen-2-yl]-isoindole-1,3-dione

: 1394868-09-7
2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-(4-fluorophenyl)thiophen-2-yl]isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride; water / 1,4-dioxane / 5.5 h / Inert atmosphere; Heating

2: N-Bromosuccinimide; dibenzoyl peroxide / 1,2-dichloro-ethane / 3 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; cesium fluoride; dibenzoyl peroxide; In 1,4-dioxane; 1,2-dichloro-ethane;
DOI:10.1021/jm3007504

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1394868-09-7
2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-(4-fluorophenyl)thiophen-2-yl]isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride; water / 1,4-dioxane / 5.5 h / Inert atmosphere; Heating

2: N-Bromosuccinimide; dibenzoyl peroxide / 1,2-dichloro-ethane / 3 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; cesium fluoride; dibenzoyl peroxide; In 1,4-dioxane; 1,2-dichloro-ethane;
DOI:10.1021/jm3007504