BenzaMide, 3-nitro-N-(2-phenylethyl)-

Base Information

• Chemical Name: BenzaMide, 3-nitro-N-(2-phenylethyl)-
• CAS No.: 326884-52-0
• Molecular Formula: C₁₅H₁₄N₂O₃
• Molecular Weight: 270.288
• Mol file: 326884-52-0.mol

Synonyms:3-nitro-N-(2-phenylethyl)benzamide

Chemical Property of BenzaMide, 3-nitro-N-(2-phenylethyl)-

Chemical Property:

Purity/Quality:

3-NITRO-N-(2-PHENYLETHYL)BENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BenzaMide, 3-nitro-N-(2-phenylethyl)-

There total 4 articles about BenzaMide, 3-nitro-N-(2-phenylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-nitro-benzaldehyde (99-61-6) + phenethylamine (64-04-0) → 3-nitro-N-(2-phenylethyl)benzamide (326884-52-0)

Guidance literature:

With tert.-butylhydroperoxide; 1-(3-sulfopropyl)pyridinium phosphotungstate; In water; at 90 ℃; for 20h; Sealed tube;

DOI:10.1039/c5ob02376a

Reference yield: 85.0%

phenethylamine (64-04-0) + 3-nitrobenzoic acid (121-92-6) → 3-nitro-N-(2-phenylethyl)benzamide (326884-52-0)

Guidance literature:

phenethylamine; With 2-(4-formyl-3-methoxyphenoxy)ethyl polystyrene; sodium tris(acetoxy)borohydride; trimethyl orthoformate; In 1,2-dichloro-ethane; at 20 ℃; for 20h;

3-nitrobenzoic acid; With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;

With trifluoroacetic acid; In dichloromethane; for 20h;

Reference yield: 57.0%

2-phenylethylamine hydrochloride (156-28-5) + 3-nitrobenzoic acid (121-92-6) → 3-nitro-N-(2-phenylethyl)benzamide (326884-52-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/acs.jmedchem.7b00443

upstream raw materials:

2-phenylethylamine hydrochloride

m-nitrobenzoic acid chloride

phenethylamine

3-nitrobenzoic acid

Downstream raw materials:

3-amino-N-(β-phenethyl)benzamide

3-(3,4-dihydro-[1]isoquinolyl)-aniline

7-Nitro-1-(3-nitrophenyl)-3,4-dihydroisochinolin

7-nitro-1-(3-nitro-phenyl)-isoquinoline

Refernces

• 1、 Fu, Renzhong,Yang, Yang,Zhang, Jin,Shao, Jintao,Xia, Xuming,Ma, Yunsheng,Yuan, Rongxin. "Direct oxidative amidation of aldehydes with amines catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions via a dual-catalysis process". . p. 1784 - 1793. Retrieved 2016/02/10.
• 2、 Tao, Bin,Boykin, David W.. "Solid phase synthesis of amides using Mukaiyama's reagent". . p. 10 - 11. Retrieved 2007/10/03.