4-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde

Base Information

• Chemical Name: 4-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde
• CAS No.: 1397291-86-9
• Molecular Formula: C₁₆H₁₂N₄O₄
• Molecular Weight: 324.296
• Mol file: 1397291-86-9.mol

Synonyms:4-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde

Chemical Property of 4-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde

There total 3 articles about 4-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-nitrophenyl azide (1516-60-5) + 4-(prop-2-ynyloxy)benzaldehyde (5651-86-5) → 4-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde (1397291-86-9)

Guidance literature:

With copper diacetate; sodium L-ascorbate; at 25 ℃; for 12h;

DOI:10.1080/00397911.2011.577263

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde (1397291-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 3 h / Reflux

1.2: 8 h / Reflux

2.1: copper(ll) sulfate pentahydrate; ascorbic acid / N,N-dimethyl-formamide; water / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; ascorbic acid; In water; N,N-dimethyl-formamide; acetone;

DOI:10.1007/s00044-016-1515-0

Reference yield:

4-nitro-aniline (100-01-6,104810-17-5) → 4-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde (1397291-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; hydrogenchloride; sodium nitrite

2: copper(ll) sulfate pentahydrate; ascorbic acid / N,N-dimethyl-formamide; water / 20 °C

With hydrogenchloride; sodium azide; copper(ll) sulfate pentahydrate; ascorbic acid; sodium nitrite; In water; N,N-dimethyl-formamide;

DOI:10.1007/s00044-016-1515-0

upstream raw materials:

4-nitrophenyl azide

4-(prop-2-ynyloxy)benzaldehyde

4-hydroxy-benzaldehyde

4-nitro-aniline