2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzyloxycarbonylaminobenzofuran

Base Information

• Chemical Name: 2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzyloxycarbonylaminobenzofuran
• CAS No.: 190786-17-5
• Molecular Formula: C₂₈H₂₇NO₆
• Molecular Weight: 473.525

Synonyms:2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzyloxycarbonylaminobenzofuran

Chemical Property of 2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzyloxycarbonylaminobenzofuran

Chemical Property:

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Technology Process of 2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzyloxycarbonylaminobenzofuran

There total 4 articles about 2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzyloxycarbonylaminobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 4-bromobutyrate (2969-81-5) → 2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzyloxycarbonylaminobenzofuran (190786-17-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, RT, 2 h

2: 88 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / N,N-dimethyl-acetamide; H₂O / 2 h / Ambient temperature

3: 1.) diphenylphosphoryl azide, Et₃N / 1.) toluene, reflux, 2 h, 2.) toluene, reflux, 8 h

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diphenylphosphoranyl azide; sodium hydride; triethylamine; In N,N-dimethyl acetamide; water;

DOI:10.1248/cpb.47.226

Reference yield:

2-(2-hydroxyphenyl)-5-formylbenzofuran (190786-01-7) → 2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzyloxycarbonylaminobenzofuran (190786-17-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, RT, 2 h

2: 88 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / N,N-dimethyl-acetamide; H₂O / 2 h / Ambient temperature

3: 1.) diphenylphosphoryl azide, Et₃N / 1.) toluene, reflux, 2 h, 2.) toluene, reflux, 8 h

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diphenylphosphoranyl azide; sodium hydride; triethylamine; In N,N-dimethyl acetamide; water;

DOI:10.1248/cpb.47.226

Reference yield:

2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-formylbenzofuran (190786-03-9) → 2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzyloxycarbonylaminobenzofuran (190786-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / N,N-dimethyl-acetamide; H₂O / 2 h / Ambient temperature

2: 1.) diphenylphosphoryl azide, Et₃N / 1.) toluene, reflux, 2 h, 2.) toluene, reflux, 8 h

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl acetamide; water;

DOI:10.1248/cpb.47.226

upstream raw materials:

2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>benzofuran-5-carboxylic acid

benzyl alcohol

Ethyl 4-bromobutyrate

2-(2-hydroxyphenyl)-5-formylbenzofuran

Downstream raw materials:

2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-(N-benzyloxycarbonyl-N-diphenylmethylamino)benzofuran

2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzofuran

2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-benzofuran

2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-(N-diphenylmethylamino)benzofuran

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