(S)-1-(3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-amine

Base Information

Chemical Name:(S)-1-(3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-amine
CAS No.:1418142-87-6
Molecular Formula:C₁₇H₁₈ClN₅
Molecular Weight:327.816
Hs Code.:

Synonyms:(S)-1-(3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-amine

Suppliers and Price of (S)-1-(3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-amine

Chemical Property:

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Technology Process of (S)-1-(3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-amine

There total 5 articles about (S)-1-(3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 5-chloro-3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidine

: 54012-73-6,80918-66-7,127294-73-9,128441-15-6
(S)-piperidin-3-amine

: 1418142-87-6
(S)-1-(3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 150 ℃; for 14h; Microwave irradiation;

Reference yield:

: 62739-01-9
3-(dimethylamino)-2-(3-chlorophenyl)acrylonitrile

: 1418142-87-6
(S)-1-(3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-amine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate; acetic acid / ethanol / 16 h / Reflux

2: sodium ethanolate / ethanol / 16 h / Reflux

3: trichlorophosphate / Reflux

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 14 h / 150 °C / Microwave irradiation

With sodium ethanolate; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; isopropyl alcohol;

Reference yield:

: 1111106-54-7
3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5(4H)-one

: 1418142-87-6
(S)-1-(3-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / Reflux

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 14 h / 150 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In isopropyl alcohol;