N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-(chloromethyl)benzamide

Base Information

Chemical Name:N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-(chloromethyl)benzamide
CAS No.:1436426-23-1
Molecular Formula:C₂₁H₂₂Cl₂F₃N₃O
Molecular Weight:460.326
Hs Code.:

Synonyms:N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-(chloromethyl)benzamide

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Chemical Property of N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-(chloromethyl)benzamide

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Technology Process of N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-(chloromethyl)benzamide

There total 4 articles about N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-(chloromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 1436426-21-9
4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 1436426-23-1
N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-(chloromethyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h; Cooling with ice;

Reference yield:

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1436426-23-1
N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-(chloromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3: ethanol; tin(ll) chloride / 1 h / 80 °C / Cooling with ice

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With ethanol; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 462073-61-6
1-(5-chloro-2-nitrophenyl)piperazine

: 1436426-23-1
N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-4-(chloromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

2: ethanol; tin(ll) chloride / 1 h / 80 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With ethanol; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane;