(R)-Benzyloxycarbonylamino-phenyl-acetic acid (1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl ester

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Chemical Name:(R)-Benzyloxycarbonylamino-phenyl-acetic acid (1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl ester
CAS No.:934422-56-7
Molecular Formula:C₂₈H₃₉NO₅Si
Molecular Weight:497.707
Hs Code.:

Synonyms:(R)-Benzyloxycarbonylamino-phenyl-acetic acid (1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl ester

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Chemical Property of (R)-Benzyloxycarbonylamino-phenyl-acetic acid (1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl ester

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Technology Process of (R)-Benzyloxycarbonylamino-phenyl-acetic acid (1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl ester

There total 7 articles about (R)-Benzyloxycarbonylamino-phenyl-acetic acid (1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 124156-70-3
tert-butyldimethylsilyl trifluoromethanesulfonate

: 934422-53-4
(1R,1'S,3'S)-(-)-3-hydroxy-1-[N-Cbz-(R)-phenylglycinoyl]oxycyclohexane

: 934422-56-7
(R)-Benzyloxycarbonylamino-phenyl-acetic acid (1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.tet.2006.12.035

Reference yield:

: 1521-51-3,113667-32-6
rac-3-bromocyclohexene

: 934422-56-7
(R)-Benzyloxycarbonylamino-phenyl-acetic acid (1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / diazobicyclo[5.4.0]undec-7-ene / benzene / Heating

2: (+/-)-camphor-10-sulfonic acid / CH₂Cl₂ / 16 h / 20 °C

3: 42 percent / tri-n-butyltin hydride; α,α'-azobisisobutyronitrile / benzene / 16 h / Heating

4: 85 percent / 2,6-lutidine / CH₂Cl₂ / 15 h / 20 °C

With 2,6-dimethylpyridine; azobisisobutyronitrile; camphor-10-sulfonic acid; tri-n-butyl-tin hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; benzene;
DOI:10.1016/j.tet.2006.12.035

Reference yield:

: 934422-51-2
[N-Cbz-(R)-phenylglycinoyl]oxycyclohex-2-ene

: 934422-56-7
(R)-Benzyloxycarbonylamino-phenyl-acetic acid (1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: (+/-)-camphor-10-sulfonic acid / CH₂Cl₂ / 16 h / 20 °C

2: 42 percent / tri-n-butyltin hydride; α,α'-azobisisobutyronitrile / benzene / 16 h / Heating

3: 85 percent / 2,6-lutidine / CH₂Cl₂ / 15 h / 20 °C

With 2,6-dimethylpyridine; azobisisobutyronitrile; camphor-10-sulfonic acid; tri-n-butyl-tin hydride; In dichloromethane; benzene;
DOI:10.1016/j.tet.2006.12.035