benzyl 9-(5-benzyloxycarbonyl-4-ethyl-3-methyl-2-pyrrolyl)-3-methylcycloocta[b]pyrrole-2-carboxylate

Base Information

Chemical Name:benzyl 9-(5-benzyloxycarbonyl-4-ethyl-3-methyl-2-pyrrolyl)-3-methylcycloocta[b]pyrrole-2-carboxylate
CAS No.:210359-44-7
Molecular Formula:C₃₄H₃₈N₂O₄
Molecular Weight:538.687
Hs Code.:

Synonyms:benzyl 9-(5-benzyloxycarbonyl-4-ethyl-3-methyl-2-pyrrolyl)-3-methylcycloocta[b]pyrrole-2-carboxylate

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Chemical Property of benzyl 9-(5-benzyloxycarbonyl-4-ethyl-3-methyl-2-pyrrolyl)-3-methylcycloocta[b]pyrrole-2-carboxylate

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Technology Process of benzyl 9-(5-benzyloxycarbonyl-4-ethyl-3-methyl-2-pyrrolyl)-3-methylcycloocta[b]pyrrole-2-carboxylate

There total 10 articles about benzyl 9-(5-benzyloxycarbonyl-4-ethyl-3-methyl-2-pyrrolyl)-3-methylcycloocta[b]pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 51089-83-9
benzyl 4-ethyl-3-methyl-1H-pyrrole-2-carboxylate

: 130611-86-8
benzyl 9-acetoxy-3-methylcycloocta[b]pyrrole-2-carboxylate

: 210359-44-7
benzyl 9-(5-benzyloxycarbonyl-4-ethyl-3-methyl-2-pyrrolyl)-3-methylcycloocta[b]pyrrole-2-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In acetic acid; at 20 ℃; for 2h;
DOI:10.1016/S0040-4020(98)00327-5

Reference yield:

: 210359-35-6
2-(2-methyl-1,3-dioxolan-2-yl)butan-1-ol

: 210359-44-7
benzyl 9-(5-benzyloxycarbonyl-4-ethyl-3-methyl-2-pyrrolyl)-3-methylcycloocta[b]pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 69 percent / conc. HCl / H₂O; ethanol / 1.5 h / Heating

2.1: 80 percent / dimethylaminopyridine / CHCl₃ / 20 °C

3.1: 95 percent / DBU / tetrahydrofuran / 20 °C

4.1: phosphorus oxychloride / pyridine / 20 °C

4.2: 32 percent / DBU / toluene / Heating

5.1: 72 percent / p-toluenesulfonic acid / acetic acid / 2 h / 20 °C

With hydrogenchloride; dmap; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In tetrahydrofuran; pyridine; ethanol; chloroform; water; acetic acid; 1.1: Hydrolysis / 2.1: Acetylation / 3.1: Cyclization / 4.1: Dehydration / 4.2: Elimination / 5.1: Condensation;
DOI:10.1016/S0040-4020(98)00327-5

Reference yield:

: 502-49-8
cycloactanone

: 210359-44-7
benzyl 9-(5-benzyloxycarbonyl-4-ethyl-3-methyl-2-pyrrolyl)-3-methylcycloocta[b]pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / sodium acetate; zinc / acetic acid / 120 - 130 °C

2: 0.60 g / CH₂Cl₂ / 16 h / 20 °C

3: 72 percent / p-toluenesulfonic acid / acetic acid / 2 h / 20 °C

With sodium acetate; toluene-4-sulfonic acid; zinc; In dichloromethane; acetic acid; 1: Cyclization / 2: Acetoxylation / 3: Condensation;
DOI:10.1016/S0040-4020(98)00327-5