(5α,7β,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-(phenylseleno)indolizine

Base Information

Chemical Name:(5α,7β,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-(phenylseleno)indolizine
CAS No.:134817-81-5
Molecular Formula:C₁₉H₂₃NOSe
Molecular Weight:360.358
Hs Code.:

Synonyms:(5α,7β,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-(phenylseleno)indolizine

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Chemical Property of (5α,7β,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-(phenylseleno)indolizine

Chemical Property:

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Technology Process of (5α,7β,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-(phenylseleno)indolizine

There total 7 articles about (5α,7β,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-(phenylseleno)indolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2179-79-5
phenyl selenocyanate

: 134817-80-4
(5α,7α,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-indolizinol

: 134817-81-5
(5α,7β,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-(phenylseleno)indolizine

Guidance literature:: With tributylphosphine; In tetrahydrofuran; for 1.5h; Heating;
DOI:10.1021/jo00016a033

Reference yield:

: 498-60-2
furan-3-carboxaldehyde

: 134817-81-5
(5α,7β,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-(phenylseleno)indolizine

Guidance literature:: Multi-step reaction with 5 steps

1: MgSO₄ / diethyl ether / 1 h / Ambient temperature

2: 72 percent / ZnCl₂ / tetrahydrofuran / 40 h / Ambient temperature

3: 83 percent / Ph₃SnH, AIBN / benzene

4: 86 percent / NaBH₄ / ethanol / 0.17 h / 0 °C

5: 63 percent / Bu₃P / tetrahydrofuran / 1.5 h / Heating

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tributylphosphine; triphenylstannane; magnesium sulfate; zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethanol; benzene;
DOI:10.1021/jo00016a033

Reference yield:

: 72476-03-0
(E)-3-methyl-4-methoxy-2-[(trimethylsilyl)oxy]-1,3-butadiene

: 134817-81-5
(5α,7β,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-(phenylseleno)indolizine

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / ZnCl₂ / tetrahydrofuran / 40 h / Ambient temperature

2: 83 percent / Ph₃SnH, AIBN / benzene

3: 86 percent / NaBH₄ / ethanol / 0.17 h / 0 °C

4: 63 percent / Bu₃P / tetrahydrofuran / 1.5 h / Heating

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tributylphosphine; triphenylstannane; zinc(II) chloride; In tetrahydrofuran; ethanol; benzene;
DOI:10.1021/jo00016a033