3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-nitrobenzoic acid

Base Information

Chemical Name:3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-nitrobenzoic acid
CAS No.:726191-34-0
Molecular Formula:C₁₁H₁₁FN₄O₄
Molecular Weight:282.231
Hs Code.:

Synonyms:3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-nitrobenzoic acid

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Chemical Property of 3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-nitrobenzoic acid

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Technology Process of 3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-nitrobenzoic acid

There total 5 articles about 3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 726191-14-6
C₉H₉N₃O₄S*HI

: 159029-28-4
1,3-diamino-2-fluoropropane

: 726191-34-0
3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-nitrobenzoic acid

Guidance literature:: With triethylamine; In DMF (N,N-dimethyl-formamide); at 85 ℃; for 3h;

Reference yield:

: HOOCC₆H₃NO₂NHCSNHCOC₆H₅

: 726191-34-0
3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-nitrobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methoxide / methanol / 1 h / 20 °C

2: ethanol / Heating

3: dimethylformamide / 100 °C

With sodium methylate; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.03.034

Reference yield:

: 618-84-8
3-amino-5-nitro-benzoic acid

: 726191-34-0
3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-nitrobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 1 h / 20 °C

2: sodium methoxide / methanol / 1 h / 20 °C

3: ethanol / Heating

4: dimethylformamide / 100 °C

With sodium methylate; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2007.03.034