(2S,3R)-3-(allyloxy)-N-[(1R,2S)-2-(allyloxy)-1-benzyl-4-phenylbutyl]-2-methyl-5-phenylpentanamide

Base Information

Chemical Name:(2S,3R)-3-(allyloxy)-N-[(1R,2S)-2-(allyloxy)-1-benzyl-4-phenylbutyl]-2-methyl-5-phenylpentanamide
CAS No.:460352-70-9
Molecular Formula:C₃₅H₄₃NO₃
Molecular Weight:525.731
Hs Code.:

Synonyms:(2S,3R)-3-(allyloxy)-N-[(1R,2S)-2-(allyloxy)-1-benzyl-4-phenylbutyl]-2-methyl-5-phenylpentanamide

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Chemical Property of (2S,3R)-3-(allyloxy)-N-[(1R,2S)-2-(allyloxy)-1-benzyl-4-phenylbutyl]-2-methyl-5-phenylpentanamide

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Technology Process of (2S,3R)-3-(allyloxy)-N-[(1R,2S)-2-(allyloxy)-1-benzyl-4-phenylbutyl]-2-methyl-5-phenylpentanamide

There total 5 articles about (2S,3R)-3-(allyloxy)-N-[(1R,2S)-2-(allyloxy)-1-benzyl-4-phenylbutyl]-2-methyl-5-phenylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 460352-62-9
(2R,3S)-3-(allyloxy)-2-methyl-5-phenylpentanoic acid

: 460352-70-9
(2S,3R)-3-(allyloxy)-N-[(1R,2S)-2-(allyloxy)-1-benzyl-4-phenylbutyl]-2-methyl-5-phenylpentanamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jo025889b

Reference yield:

: 460352-59-4
(4R)-3-[(2S,3R)-3-(allyloxy)-2-benzyl-5-phenylpentanoyl]-4-benzyl-1,3-oxazolidin-2-one

: 460352-70-9
(2S,3R)-3-(allyloxy)-N-[(1R,2S)-2-(allyloxy)-1-benzyl-4-phenylbutyl]-2-methyl-5-phenylpentanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; H₂O₂ / H₂O; tetrahydrofuran / 3.5 h / 0 - 20 °C

2.1: triethylamine; diphenylphosphoryl azide / acetonitrile / 1.5 h / 50 °C

2.2: hydrochloric acid / H₂O; acetonitrile / Heating

3.1: benzotriazol-1-yloxy-tris(dimethylamino)phosphonium PF₆^(1-); ethyldiisopropylamine / acetonitrile / 1 h / 20 °C

With lithium hydroxide; diphenylphosphoranyl azide; dihydrogen peroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; acetonitrile; 2.2: Curtius rearrangement;
DOI:10.1021/jo025889b

Reference yield:

: C₂₁H₂₃NO₂

: 460352-70-9
(2S,3R)-3-(allyloxy)-N-[(1R,2S)-2-(allyloxy)-1-benzyl-4-phenylbutyl]-2-methyl-5-phenylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrochloric acid / H₂O / Heating

2: benzotriazol-1-yloxy-tris(dimethylamino)phosphonium PF₆^(1-); ethyldiisopropylamine / acetonitrile / 1 h / 20 °C

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In water; acetonitrile; 1: Curtius rearrangement;
DOI:10.1021/jo025889b