(R)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-en-1-ol

Base Information

Chemical Name:(R)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-en-1-ol
CAS No.:461044-27-9
Molecular Formula:C₁₇H₂₄O₄
Molecular Weight:292.375
Hs Code.:

Synonyms:(R)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-en-1-ol

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Chemical Property of (R)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-en-1-ol

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Technology Process of (R)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-en-1-ol

There total 6 articles about (R)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 461044-26-8
(S)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-enoic acid methyl ester

: 461044-27-9
(R)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-en-1-ol

Guidance literature:: With lithium aluminium tetrahydride; at 0 - 20 ℃;
DOI:10.1002/1521-3773(20020415)41:8<1404::AID-ANIE1404>3.0.CO;2-G

Reference yield:

: 461044-22-4
(4S,5S)-4-Hydroxy-5-methyl-tetrahydro-pyran-2-one

: 461044-27-9
(R)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / lithium diisopropylamide / hexamethylphosphoric acid triamide / 36 h / -78 °C

2: 60 percent / 30 °C

3: 95 percent / 10-camphorsulfonic acid

4: 90 percent / LiAlH₄ / 0 - 20 °C

With lithium aluminium tetrahydride; (1S)-10-camphorsulfonic acid; lithium diisopropyl amide; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1002/1521-3773(20020415)41:8<1404::AID-ANIE1404>3.0.CO;2-G

Reference yield:

: 473251-43-3
(4S,5S)-5-Methyl-tetrahydro-pyran-2,4-diol

: 461044-27-9
(R)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / Br₂; BaCO₃ / 12 h

2: 85 percent / lithium diisopropylamide / hexamethylphosphoric acid triamide / 36 h / -78 °C

3: 60 percent / 30 °C

4: 95 percent / 10-camphorsulfonic acid

5: 90 percent / LiAlH₄ / 0 - 20 °C

With lithium aluminium tetrahydride; (1S)-10-camphorsulfonic acid; bromine; barium carbonate; lithium diisopropyl amide; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1002/1521-3773(20020415)41:8<1404::AID-ANIE1404>3.0.CO;2-G