2-((2S,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile

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Chemical Name:2-((2S,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1610033-17-4
Molecular Formula:C₂₆H₃₂FN₃O₃
Molecular Weight:453.557
Hs Code.:

Synonyms:2-((2S,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of 2-((2S,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile

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Technology Process of 2-((2S,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile

There total 6 articles about 2-((2S,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 773837-37-9
sodium cyanide

: 1610033-15-2
((2R,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)methanol

: 1610033-17-4
2-((2S,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: ((2R,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)methanol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

sodium cyanide; In dimethyl sulfoxide; at 50 ℃;

Reference yield:

: 1610033-00-5
1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl 4-methylbenzenesulfonate

: 1610033-17-4
2-((2S,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 55 °C / Sealed tube

2.1: sodium hydroxide / butan-1-ol / Inert atmosphere

2.2: 90 °C / Sealed tube

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0 - 20 °C

3.2: 50 °C

With caesium carbonate; methanesulfonyl chloride; triethylamine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1610032-99-9
1-(2-fluoro-5-methoxyphenyl)piperidin-4-ol

: 1610033-17-4
2-((2S,4R)-4-ethoxy-1-(4-(1-(2-fluoro-5-methoxyphenyl)piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 17 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 55 °C / Sealed tube

3.1: sodium hydroxide / butan-1-ol / Inert atmosphere

3.2: 90 °C / Sealed tube

4.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0 - 20 °C

4.2: 50 °C

With pyridine; caesium carbonate; methanesulfonyl chloride; triethylamine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide; butan-1-ol;