Cyclopropylmethyl-(4-methoxy-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl-amine

Base Information

Chemical Name:Cyclopropylmethyl-(4-methoxy-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl-amine
CAS No.:345309-45-7
Molecular Formula:C₂₂H₂₇NO
Molecular Weight:321.462
Hs Code.:

Synonyms:Cyclopropylmethyl-(4-methoxy-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl-amine

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Chemical Property of Cyclopropylmethyl-(4-methoxy-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl-amine

Chemical Property:

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Technology Process of Cyclopropylmethyl-(4-methoxy-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl-amine

There total 4 articles about Cyclopropylmethyl-(4-methoxy-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80232-33-3,80232-34-4
3-(N-methyl-N-cyclopropanecarboxamido)-1-methoxy-1-phenyltetralin

: 345309-45-7
Cyclopropylmethyl-(4-methoxy-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl-amine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 25 ℃; for 8h;
DOI:10.1021/jm00345a005

Reference yield:

: 718-08-1
ethyl 3-oxo-4-phenylbutyrate

: 345309-45-7
Cyclopropylmethyl-(4-methoxy-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl-amine

Guidance literature:: Multi-step reaction with 8 steps

1: methanol / 25 °C

2: NaBH₃CN, HCl gas / methanol

3: pyridine / benzene / 2 h / 25 °C

4: 0.2 N NaOH / tetrahydrofuran / 1 h / 25 °C

5: 41 percent / anhydrous HF / 10 h

6: diethyl ether / 6 h / 25 °C

7: 1.) NaH / 1.) DMF, 2.) DMF, 21 deg C, 10 h

8: LiAlH₄ / diethyl ether / 8 h / 25 °C

With pyridine; hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; hydrogen fluoride; sodium hydride; sodium cyanoborohydride; In tetrahydrofuran; methanol; diethyl ether; benzene;
DOI:10.1021/jm00345a005

Reference yield:

: (Z)-3-Methylamino-4-phenyl-but-2-enoic acid ethyl ester

: 345309-45-7
Cyclopropylmethyl-(4-methoxy-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl-amine

Guidance literature:: Multi-step reaction with 7 steps

1: NaBH₃CN, HCl gas / methanol

2: pyridine / benzene / 2 h / 25 °C

3: 0.2 N NaOH / tetrahydrofuran / 1 h / 25 °C

4: 41 percent / anhydrous HF / 10 h

5: diethyl ether / 6 h / 25 °C

6: 1.) NaH / 1.) DMF, 2.) DMF, 21 deg C, 10 h

7: LiAlH₄ / diethyl ether / 8 h / 25 °C

With pyridine; hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; hydrogen fluoride; sodium hydride; sodium cyanoborohydride; In tetrahydrofuran; methanol; diethyl ether; benzene;
DOI:10.1021/jm00345a005