(2E)-2,3-Dideoxy-1-cyano-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene

Base Information

Chemical Name:(2E)-2,3-Dideoxy-1-cyano-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene
CAS No.:126502-51-0
Molecular Formula:C₂₂H₃₁NO₅
Molecular Weight:389.492
Hs Code.:

Synonyms:(2E)-2,3-Dideoxy-1-cyano-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene

Suppliers and Price of (2E)-2,3-Dideoxy-1-cyano-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2E)-2,3-Dideoxy-1-cyano-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E)-2,3-Dideoxy-1-cyano-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene

There total 12 articles about (2E)-2,3-Dideoxy-1-cyano-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 143-33-9,25596-52-5
sodium cyanide

: 126502-49-6
4-((E)-(1S,2R,3S)-2-Benzyloxy-6-chloro-1,3-dimethoxy-5-methyl-hex-4-enyl)-2,2-dimethyl-[1,3]dioxolane

: 126502-51-0
(E)-(5S,6R,7S)-6-Benzyloxy-7-(2,2-dimethyl-[1,3]dioxolan-4-yl)-5,7-dimethoxy-3-methyl-hept-3-enenitrile

Guidance literature:: In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jo00262a006

Reference yield: 69.0%

: 143-33-9,25596-52-5
sodium cyanide

: 126502-49-6
(2E)-2,3-Dideoxy-1-chloro-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene

: 126502-50-9
(E)-(5S,6R,7S)-6-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5,7-dimethoxy-3-methyl-hept-2-enenitrile

: 126502-51-0
(2E)-2,3-Dideoxy-1-cyano-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene

Guidance literature:: In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1021/jo00296a041

Reference yield:

: 126502-45-2
(3S,4R,5S)-4-Benzyloxy-3,5-dimethoxy-hexane-1,2,6-triol

: 126502-51-0
(E)-(5S,6R,7S)-6-Benzyloxy-7-(2,2-dimethyl-[1,3]dioxolan-4-yl)-5,7-dimethoxy-3-methyl-hept-3-enenitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / TsOH, 3-A molecular sieves / Ambient temperature

2: (ClCO)2, DMSO, TEA / CH₂Cl₂ / -78 °C

3: CH₂Cl₂ / from 0 deg C to RT

4: 100 percent / LiEt₃BH / tetrahydrofuran / -78 - -20 °C

5: 67 percent / MsCl, LiCl, s-collidine / dimethylformamide / 0 °C

6: 69 percent / dimethylformamide / Ambient temperature

With 2,4,6-trimethyl-pyridine; oxalyl dichloride; 3 A molecular sieve; TEA; lithium triethylborohydride; toluene-4-sulfonic acid; dimethyl sulfoxide; methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00262a006