4-(1-(5-(5-(azetidin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

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Chemical Name:4-(1-(5-(5-(azetidin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile
CAS No.:1399176-09-0
Molecular Formula:C₃₀H₃₀N₆O
Molecular Weight:490.608
Hs Code.:

Synonyms:4-(1-(5-(5-(azetidin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

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Chemical Property of 4-(1-(5-(5-(azetidin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

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Technology Process of 4-(1-(5-(5-(azetidin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

There total 14 articles about 4-(1-(5-(5-(azetidin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1399176-99-8
4-(1-(5-(4-(azetidin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

: C₂₁H₂₀N₂O₂

: 1399176-08-9
4-(1-(2,4-dimethyl-5-(6-(methylsulfonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzoyl)piperidin-4-yl)benzonitrile

: 1415387-42-6
4-(1-(5-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-2,4-dimethyllbenzoyl)piperidin-4-yl)benzonitrile

: 1399176-07-8
4-(1-(2,4-dimethyl-5-(6-(methylsulfonyl)-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl)piperidin-4-yl)benzonitrile

: 1399176-09-0
4-(1-(5-(5-(azetidin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) chloride; potassium hydroxide; 1,10-Phenanthroline

2: potassium iodide; potassium iodate / acetic acid

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide

With bis-triphenylphosphine-palladium(II) chloride; potassium iodate; copper(l) iodide; 1,10-Phenanthroline; potassium iodide; copper(l) chloride; potassium hydroxide; In acetic acid;
DOI:10.1016/j.dyepig.2013.12.016

Reference yield:

: 1399181-27-1
4-(1-(5-formyl-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

: C₈H₁₂N₄

: 1399176-09-0
4-(1-(5-(5-(azetidin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

Guidance literature:: With sodium metabisulfite; In N,N-dimethyl-formamide; at 100 ℃; for 22h;
DOI:10.1021/ml300335r

Reference yield:

: 742081-03-4
5-iodo-2,4-dimethylbenzoic acid

: 1399176-09-0
4-(1-(5-(5-(azetidin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

3.1: sodium metabisulfite / N,N-dimethyl-formamide / 22 h / 100 °C

With sodium metabisulfite; n-butyllithium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ml300335r