(S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

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Chemical Name:(S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester
CAS No.:1381812-31-2
Molecular Formula:C₃₄H₅₀N₄O₅Si
Molecular Weight:622.88
Hs Code.:

(S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Synonyms:(S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

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Chemical Property of (S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

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Technology Process of (S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

There total 3 articles about (S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381811-94-4
(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

: 1381812-31-2
(S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Guidance literature:: (S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1.5h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Product distribution / selectivity;

Reference yield:

: 45804-94-2
3-Ethenylbenzyl alcohol

: 1381812-31-2
(S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 6 h / 20 - 40 °C / Inert atmosphere

2: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1.5 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; sodium hydride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 19955-99-8
3-ethenylbenzaldehyde

: 1381812-31-2
(S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 0.25 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran; mineral oil / 6 h / 40 °C / Inert atmosphere

3: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 2 h / 0 °C

With sodium tetrahydroborate; trimethylsilyl trifluoromethanesulfonate; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1021/acs.jmedchem.6b01329