4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-2,2-difluorobutyl acetate

Base Information

Chemical Name:4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-2,2-difluorobutyl acetate
CAS No.:1221502-57-3
Molecular Formula:C₁₆H₁₆BrF₃N₂O₂
Molecular Weight:405.214
Hs Code.:

Synonyms:4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-2,2-difluorobutyl acetate

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Chemical Property of 4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-2,2-difluorobutyl acetate

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Technology Process of 4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-2,2-difluorobutyl acetate

There total 12 articles about 4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-2,2-difluorobutyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₆BrFN₂O₃

: 1221502-57-3
4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-2,2-difluorobutyl acetate

Guidance literature:: With diethylamino-sulfur trifluoride; In toluene; at 40 ℃; for 24h;
DOI:10.1016/j.bmc.2014.07.038

Reference yield:

: 1221503-47-4
4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]butan-2-ol

: 1221502-57-3
4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-2,2-difluorobutyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodane / toluene / 12 h / 0 - 20 °C

2.1: triethylamine / toluene / 0.5 h / 0 °C

3.1: potassium hydrogencarbonate / toluene / 3 h / 20 °C

3.2: 1 h / 20 °C

4.1: diethylamino-sulfur trifluoride / toluene / 24 h / 40 °C

With diethylamino-sulfur trifluoride; potassium hydrogencarbonate; Dess-Martin periodane; triethylamine; In toluene; 1.1: |Dess-Martin Oxidation;
DOI:10.1016/j.bmc.2014.07.038

Reference yield:

: 1221503-46-3
4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]butan-2-one

: 1221502-57-3
4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-2,2-difluorobutyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / toluene / 0.5 h / 0 °C

2.1: potassium hydrogencarbonate / toluene / 3 h / 20 °C

2.2: 1 h / 20 °C

3.1: diethylamino-sulfur trifluoride / toluene / 24 h / 40 °C

With diethylamino-sulfur trifluoride; potassium hydrogencarbonate; triethylamine; In toluene;
DOI:10.1016/j.bmc.2014.07.038