methyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Base Information

Chemical Name:methyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate
CAS No.:1399845-59-0
Molecular Formula:C₂₀H₂₂BrN₅O₄
Molecular Weight:476.33
Hs Code.:

Synonyms:methyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

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Chemical Property of methyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

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Technology Process of methyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

There total 5 articles about methyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1399845-58-9
methyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

: 1399845-59-0
methyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Guidance literature:: With ammonium acetate; In xylene; at 140 ℃; for 4h; Sealed tube;

Reference yield:

: 1399845-57-8
(1S,9S)-9-(methoxycarbonylamino)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

: 1399845-59-0
methyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / HATU / N,N-dimethyl-formamide / 4 h / 20 °C

2: ammonium acetate / xylenes / 4 h / 140 °C / Sealed vessel

With ammonium acetate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; xylenes;

Reference yield:

: 106928-72-7
(1S,9S)-t-butyl 1,2,3,4,7,8,9,10-octahydro-6,10-dioxo-9-phthalimidopyridazino<1,2-a><1,2>diazepine-1-carboxylate

: 1399845-59-0
methyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine / ethanol / 3 h / 20 °C

2: sodium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / HATU / N,N-dimethyl-formamide / 4 h / 20 °C

5: ammonium acetate / xylenes / 4 h / 140 °C / Sealed vessel

With ammonium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; hydrazine; HATU; In ethanol; dichloromethane; N,N-dimethyl-formamide; xylenes;