1-[3,5-dichloro-4-(3-ethoxycarbonylpropyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea

Base Information

Chemical Name:1-[3,5-dichloro-4-(3-ethoxycarbonylpropyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea
CAS No.:229178-83-0
Molecular Formula:C₁₈H₁₄Cl₂F₂N₂O₅
Molecular Weight:447.222
Hs Code.:

Synonyms:1-[3,5-dichloro-4-(3-ethoxycarbonylpropyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea

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Chemical Property of 1-[3,5-dichloro-4-(3-ethoxycarbonylpropyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea

Chemical Property:

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Technology Process of 1-[3,5-dichloro-4-(3-ethoxycarbonylpropyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea

There total 3 articles about 1-[3,5-dichloro-4-(3-ethoxycarbonylpropyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 229178-82-9
1-[3,5-dichloro-4-[3-(ethoxycarbonyl)propyloxy]phenyl]-3-(2,6-difluorobenzoyl)urea

: 229178-83-0
1-[3,5-dichloro-4-(3-ethoxycarbonylpropyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea

Guidance literature:: With potassium hydroxide; In methanol; at 25 ℃; for 3h; Alkaline hydrolysis;
DOI:10.1021/jf9812984

Reference yield:

: 5930-28-9
4-amino-2,6-dichlorophenol

: 229178-83-0
1-[3,5-dichloro-4-(3-ethoxycarbonylpropyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / K₂CO₃ / dimethylsulfoxide / 7 h / 25 °C

2: 87 percent / benzene / 6 h / 40 °C

3: 67 percent / aq. KOH / methanol / 3 h / 25 °C / Alkaline hydrolysis

With potassium hydroxide; potassium carbonate; In methanol; dimethyl sulfoxide; benzene; 1: Condensation / 2: Addition / 3: Hydrolysis;
DOI:10.1021/jf9812984

Reference yield:

: 229178-81-8
3,5-dichloro-4-[3-(ethoxycarbonyl)propyloxy]aniline

: 229178-83-0
1-[3,5-dichloro-4-(3-ethoxycarbonylpropyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / benzene / 6 h / 40 °C

2: 67 percent / aq. KOH / methanol / 3 h / 25 °C / Alkaline hydrolysis

With potassium hydroxide; In methanol; benzene; 1: Addition / 2: Hydrolysis;
DOI:10.1021/jf9812984