N-(4-acetyl-5-(2-chloro-8-methylquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-o-tolylacetamide

Base Information

Chemical Name:N-(4-acetyl-5-(2-chloro-8-methylquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-o-tolylacetamide
CAS No.:1313027-82-5
Molecular Formula:C₂₃H₂₁ClN₄O₂S
Molecular Weight:452.964
Hs Code.:

Synonyms:N-(4-acetyl-5-(2-chloro-8-methylquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-o-tolylacetamide

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Chemical Property of N-(4-acetyl-5-(2-chloro-8-methylquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-o-tolylacetamide

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Technology Process of N-(4-acetyl-5-(2-chloro-8-methylquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-o-tolylacetamide

There total 4 articles about N-(4-acetyl-5-(2-chloro-8-methylquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-o-tolylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 104827-59-0
1-((2-chloro-8-methylquinolin-3-yl)methylene)-4-o-tolylthiosemicarbazide

: 108-24-7
acetic anhydride

: 1313027-82-5
N-(4-acetyl-5-(2-chloro-8-methylquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-o-tolylacetamide

Guidance literature:: Reflux;
DOI:10.1016/j.ejmech.2011.04.013

Reference yield:

: 73568-26-0
2-chloro-8-methyl-quinoline-3-carbaldehyde

: 614-10-8
4-(2-methylphenyl)-3-thiosemicarbazide

: 1313027-82-5
N-(4-acetyl-5-(2-chloro-8-methylquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-o-tolylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol

1.2: 12 h / 60 °C

2.1: Reflux

In ethanol;
DOI:10.1016/j.ejmech.2011.04.013

Reference yield:

: 53278-55-0
o-Toluidino-dithiocarbamyl-essigsaeure

: 1313027-82-5
N-(4-acetyl-5-(2-chloro-8-methylquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-o-tolylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate

2.1: ethanol

2.2: 12 h / 60 °C

3.1: Reflux

With hydrazine hydrate; In ethanol;
DOI:10.1016/j.ejmech.2011.04.013