Vinflunine (ditartrate)

Base Information

Chemical Name:Vinflunine (ditartrate)
CAS No.:194468-36-5
Molecular Formula:2C₄H₆O₆*C₄₅H₅₄F₂N₄O₈
Molecular Weight:1117.12
Hs Code.:
European Community (EC) Number:685-342-4
UNII:33MG53C7XW
DSSTox Substance ID:DTXSID80870081
NCI Thesaurus Code:C76266
Wikidata:Q27256285
Mol file:194468-36-5.mol

Synonyms:Vinflunine ditartrate;Vinflunine (ditartrate);194468-36-5;Vinflunine ditartrate [USAN];33MG53C7XW;Vinflunine bitartrate;BMS-710485;F-12158;(2R,3R)-2,3-dihydroxybutanedioic acid;methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-4-[(12S,14S,16R)-16-(1,1-difluoroethyl)-12-methoxycarbonyl-1,10-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraen-12-yl]-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;UNII-33MG53C7XW;F 12158;HY-B0628B;DTXSID80870081;VINFLUNINE DITARTRATE [MI];VINFLUNINE TARTRATE [MART.];VINFLUNINE DITARTRATE [WHO-DD];CS-0109240;Q27256285;4'-Deoxy-20',20'-difluoro-8'-norvincaleucoblastine ditartrate;4'-DEOXY-20',20'-DIFLUORO-8'-NORVINCALEUKOBLASTINE BITARTRATE;Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-((2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta,3beta,4beta,5alpha,12R,19alpha)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2)

Suppliers and Price of Vinflunine (ditartrate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
VinflunineDitartrate
100mg
$ 1485.00

Medical Isotopes, Inc.
VinflunineDitartrate
50 mg
$ 2200.00

Medical Isotopes, Inc.
VinflunineDitartrate
5 mg
$ 650.00

ChemScene
Vinflunineditartrate
5mg
$ 350.00

Biosynth Carbosynth
Vinflunine ditartrate
1 mg
$ 122.00

Biosynth Carbosynth
Vinflunine ditartrate
10 mg
$ 540.00

Biosynth Carbosynth
Vinflunine ditartrate
25 mg
$ 1075.00

Biosynth Carbosynth
Vinflunine ditartrate
2 mg
$ 196.00

Biosynth Carbosynth
Vinflunine ditartrate
5 mg
$ 340.00

AvaChem
Vinflunine Ditartrate
10mg
$ 245.00

Total 13 raw suppliers

Chemical Property of Vinflunine (ditartrate)

Chemical Property:

Melting Point:244-246°C (dec)
PSA：363.99000
LogP:0.77430
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:25
Rotatable Bond Count:16
Exact Mass:1116.42384683
Heavy Atom Count:79
Complexity:1850

Purity/Quality:

97% ^*data from raw suppliers

VinflunineDitartrate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC12C=CCN3C1C4(CC3)C(C(C2OC(=O)C)(C(=O)OC)O)N(C5=CC(=C(C=C45)C6(CC7CC(CN(C7)CC8=C6NC9=CC=CC=C89)C(C)(F)F)C(=O)OC)OC)C.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O
Isomeric SMILES:CC[C@@]12C=CCN3[C@@H]1[C@]4(CC3)[C@H]([C@]([C@@H]2OC(=O)C)(C(=O)OC)O)N(C5=CC(=C(C=C45)[C@]6(C[C@@H]7C[C@H](CN(C7)CC8=C6NC9=CC=CC=C89)C(C)(F)F)C(=O)OC)OC)C.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
Recent EU Clinical Trials:A Phase III Randomized Clinical Trial of Pembrolizumab (MK-3475) versus Paclitaxel, Docetaxel or Vinflunine in Subjects with Recurrent or Progressive Metastatic Urothelial Cancer
Uses Vinflunine Ditartrate can be used as Semisynthetic Vinca alkaloid with microtubule destabilizing and antiangiogenic activity; derivative of Vinorelbine. Vinflunine is a semisynthetic Vinca alkaloid with microtubule destabilizing and antiangiogenic activity. Vinflunine is a derivative of Vinorelbine. Vinflunine is used as an antineoplastic.
Clinical Use Vinflunine ditartrate is a second generation difluorinated analog of the naturally-occuring substance vinorelbine and it is approved for the treatment of non-small cell lung cancer, metastatic breast cancer and ovarian cancer. Vinflunine, a tubulin polymerization inhibitor, belongs to the vinca alkaloid class of anti-cancer agents. Introduction of the difluoro group of vinflunine dramatically improved antitumor activity of the parent vinorelbine structure. Vinflunine was discovered by Pierre Fabre Laboratories and in 2004 was licensed to Bristol-Myers Squibb for development and commercialization. In 2007, the rights to venflunine were returned to Pierre Fabre which completed its development.

Technology Process of Vinflunine (ditartrate)

There total 1 articles about Vinflunine (ditartrate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: