(S_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-methanephosphonothioanilidate

Base Information

• Chemical Name: (S_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-methanephosphonothioanilidate
• CAS No.: 185685-40-9
• Molecular Formula: C₄₄H₄₃N₄O₇PS
• Molecular Weight: 802.888
• Mol file: 185685-40-9.mol

Synonyms:(S_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-methanephosphonothioanilidate

Chemical Property of (S_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-methanephosphonothioanilidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (S_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-methanephosphonothioanilidate

There total 1 articles about (S_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-methanephosphonothioanilidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyldichlorophosphane (676-83-5) + 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) + aniline (62-53-3) → (RP)-5'-O-dimethoxytrityl-N4-benzoylcytidine 3'-O-methanephosphonothioanilidate (185685-38-5) + (SP)-5'-O-dimethoxytrityl-N4-benzoylcytidine 3'-O-methanephosphonothioanilidate (185685-40-9)

Guidance literature:

With sulfur; triethylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -40 deg C, 1 h, 2.) room temperature, overnight;

DOI:10.1021/jo980225g

Reference yield: 85.0%

(SP)-5'-O-dimethoxytrityl-N4-benzoylcytidine 3'-O-methanephosphonothioanilidate (185685-40-9) → (RP)-5'-O-dimethoxytritylN4-benzoylcytidine 3'-O-methanephosphonoanilidate

Guidance literature:

With Oxone; sodium acetate buffer; In tetrahydrofuran; methanol; Ambient temperature;

DOI:10.1016/S0960-894X(98)00492-2

upstream raw materials:

methyldichlorophosphane

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

aniline