{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-5-[2-(4-methoxy-phenoxy)-ethyl]-3-propyl-tetrahydro-pyran-4-yl}-methanol

Base Information

Chemical Name:{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-5-[2-(4-methoxy-phenoxy)-ethyl]-3-propyl-tetrahydro-pyran-4-yl}-methanol
CAS No.:157117-04-9
Molecular Formula:C₃₆H₅₀O₆Si
Molecular Weight:606.875
Hs Code.:

Synonyms:{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-5-[2-(4-methoxy-phenoxy)-ethyl]-3-propyl-tetrahydro-pyran-4-yl}-methanol

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Chemical Property of {(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-5-[2-(4-methoxy-phenoxy)-ethyl]-3-propyl-tetrahydro-pyran-4-yl}-methanol

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Technology Process of {(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-5-[2-(4-methoxy-phenoxy)-ethyl]-3-propyl-tetrahydro-pyran-4-yl}-methanol

There total 13 articles about {(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-5-[2-(4-methoxy-phenoxy)-ethyl]-3-propyl-tetrahydro-pyran-4-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157116-97-7
Acetic acid (1R,2S,3R,4R,5R)-4-allyl-2-benzyloxy-6,8-dioxa-bicyclo[3.2.1]oct-3-yl ester

: 157117-04-9
{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-5-[2-(4-methoxy-phenoxy)-ethyl]-3-propyl-tetrahydro-pyran-4-yl}-methanol

Guidance literature:: Multi-step reaction with 13 steps

2: DEAD-Ph₃P / CH₂Cl₂ / Ambient temperature

3: H₂ / Pd/C / methanol

4: Et₃N / CH₂Cl₂ / -10 °C

5: MeONa / methanol / Ambient temperature

6: diethyl ether / Ambient temperature

7: H₂ / Pd/C / methanol

8: H⁽¹⁺⁾

9: pyridine

10: Swern oxidation

11: MeLi / tetrahydrofuran / -78 °C

12: methylaluminum bis-(4-bromo-2,6-di-tert-butyl-phenoxide) (MABR) / CH₂Cl₂ / -78 °C

13: NaBH₄ / 0.25 h / -20 °C

With pyridine; sodium tetrahydroborate; methyllithium; hydrogen; sodium methylate; hydrogen cation; methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)75797-2

Reference yield:

: Acetic acid (1R,2S,3R,4R,5R)-2-benzyloxy-4-(2-hydroxy-ethyl)-6,8-dioxa-bicyclo[3.2.1]oct-3-yl ester

: 157117-04-9
{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-5-[2-(4-methoxy-phenoxy)-ethyl]-3-propyl-tetrahydro-pyran-4-yl}-methanol

Guidance literature:: Multi-step reaction with 12 steps

1: DEAD-Ph₃P / CH₂Cl₂ / Ambient temperature

2: H₂ / Pd/C / methanol

3: Et₃N / CH₂Cl₂ / -10 °C

4: MeONa / methanol / Ambient temperature

5: diethyl ether / Ambient temperature

6: H₂ / Pd/C / methanol

7: H⁽¹⁺⁾

8: pyridine

9: Swern oxidation

10: MeLi / tetrahydrofuran / -78 °C

11: methylaluminum bis-(4-bromo-2,6-di-tert-butyl-phenoxide) (MABR) / CH₂Cl₂ / -78 °C

12: NaBH₄ / 0.25 h / -20 °C

With pyridine; sodium tetrahydroborate; methyllithium; hydrogen; sodium methylate; hydrogen cation; methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)75797-2

Reference yield:

: 157116-98-8
Acetic acid (1R,2S,3R,4R,5R)-2-benzyloxy-4-[2-(4-methoxy-phenoxy)-ethyl]-6,8-dioxa-bicyclo[3.2.1]oct-3-yl ester

: 157117-04-9
{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-5-[2-(4-methoxy-phenoxy)-ethyl]-3-propyl-tetrahydro-pyran-4-yl}-methanol

Guidance literature:: Multi-step reaction with 11 steps

1: H₂ / Pd/C / methanol

2: Et₃N / CH₂Cl₂ / -10 °C

3: MeONa / methanol / Ambient temperature

4: diethyl ether / Ambient temperature

5: H₂ / Pd/C / methanol

6: H⁽¹⁺⁾

7: pyridine

8: Swern oxidation

9: MeLi / tetrahydrofuran / -78 °C

10: methylaluminum bis-(4-bromo-2,6-di-tert-butyl-phenoxide) (MABR) / CH₂Cl₂ / -78 °C

11: NaBH₄ / 0.25 h / -20 °C

With pyridine; sodium tetrahydroborate; methyllithium; hydrogen; sodium methylate; hydrogen cation; methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)75797-2