N-((3S,6R,7R,8aR)-3-benzyl-8a-methyl-2,5-dioxo-7-phenyl-6-propylhexahydro-2H-oxazolo[3,2-a]pyridin-6-yl)benzamide

Base Information

• Chemical Name: N-((3S,6R,7R,8aR)-3-benzyl-8a-methyl-2,5-dioxo-7-phenyl-6-propylhexahydro-2H-oxazolo[3,2-a]pyridin-6-yl)benzamide
• CAS No.: 1423044-89-6
• Molecular Formula: C₃₁H₃₂N₂O₄
• Molecular Weight: 496.606

Synonyms:N-((3S,6R,7R,8aR)-3-benzyl-8a-methyl-2,5-dioxo-7-phenyl-6-propylhexahydro-2H-oxazolo[3,2-a]pyridin-6-yl)benzamide

Chemical Property of N-((3S,6R,7R,8aR)-3-benzyl-8a-methyl-2,5-dioxo-7-phenyl-6-propylhexahydro-2H-oxazolo[3,2-a]pyridin-6-yl)benzamide

Chemical Property:

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Technology Process of N-((3S,6R,7R,8aR)-3-benzyl-8a-methyl-2,5-dioxo-7-phenyl-6-propylhexahydro-2H-oxazolo[3,2-a]pyridin-6-yl)benzamide

There total 2 articles about N-((3S,6R,7R,8aR)-3-benzyl-8a-methyl-2,5-dioxo-7-phenyl-6-propylhexahydro-2H-oxazolo[3,2-a]pyridin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + (R)-4-((R)-3-oxo-1-phenylbutyl)-2-phenyl-4-propyloxazol-5(4H)-one (1242985-35-8) → N-((3S,6R,7R,8aR)-3-benzyl-8a-methyl-2,5-dioxo-7-phenyl-6-propylhexahydro-2H-oxazolo[3,2-a]pyridin-6-yl)benzamide (1423044-89-6)

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 75 ℃; for 42h; Inert atmosphere; Molecular sieve;

DOI:10.1002/chem.201202455

Reference yield: 35.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + 4-(3-oxo-1-phenylbutyl)-2-phenyl-4-propyloxazol-5(4H)-one → N-((3S,6R,7R,8aR)-3-benzyl-8a-methyl-2,5-dioxo-7-phenyl-6-propylhexahydro-2H-oxazolo[3,2-a]pyridin-6-yl)benzamide (1423044-89-6) + N-((3S,6S,7S,8aS)-3-benzyl-8a-methyl-2,5-dioxo-7-phenyl-6-propylhexahydro-2H-oxazolo[3,2-a]pyridin-6-yl)benzamide (1423044-92-1)

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 70 ℃; for 46h; Inert atmosphere;

DOI:10.1002/chem.201202455

Reference yield: 64.0%

N-((3S,6R,7R,8aR)-3-benzyl-8a-methyl-2,5-dioxo-7-phenyl-6-propylhexahydro-2H-oxazolo[3,2-a]pyridin-6-yl)benzamide (1423044-89-6) → (2R,3R,6S,11bR)-3-benzamido-11b-methyl-4-oxo-2-phenyl-3-propyl-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-6-carboxylic acid

Guidance literature:

With titanium tetrachloride; In 1,2-dichloro-ethane; at 80 ℃; for 44h; Inert atmosphere;

DOI:10.1002/chem.201202455

upstream raw materials:

L-phenylalanine

(R)-4-((R)-3-oxo-1-phenylbutyl)-2-phenyl-4-propyloxazol-5(4H)-one

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