4-[Bis(4-methoxyphenyl)methylene]tetrahydro-2H-pyran

Base Information

• Chemical Name: 4-[Bis(4-methoxyphenyl)methylene]tetrahydro-2H-pyran
• CAS No.: 96835-19-7
• Molecular Formula: C₂₀H₂₂O₃
• Molecular Weight: 310.393
• DSSTox Substance ID: DTXSID601218672
• Mol file: 96835-19-7.mol

Synonyms:DTXSID601218672;4-[Bis(4-methoxyphenyl)methylene]tetrahydro-2H-pyran;96835-19-7

Chemical Property of 4-[Bis(4-methoxyphenyl)methylene]tetrahydro-2H-pyran

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 310.15689456
• Heavy Atom Count: 23
• Complexity: 354

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=C2CCOCC2)C3=CC=C(C=C3)OC

Technology Process of 4-[Bis(4-methoxyphenyl)methylene]tetrahydro-2H-pyran

There total 3 articles about 4-[Bis(4-methoxyphenyl)methylene]tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Bis-(4-methoxy-phenyl)-(tetrahydro-pyran-4-yl)-methanol (96835-18-6) → 4-[Bis-(4-methoxy-phenyl)-methylene]-tetrahydro-pyran (96835-19-7)

Guidance literature:

With potassium hydrogensulfate; at 160 - 170 ℃; for 1h;

Reference yield:

ethyl tetrahydro-2H-pyran-4-carboxylate (96835-17-5) → 4-[Bis-(4-methoxy-phenyl)-methylene]-tetrahydro-pyran (96835-19-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Mg / 1) ether

2: 0.75 g / KHSO₄ / 1 h / 160 - 170 °C

With potassium hydrogensulfate; magnesium;

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → 4-[Bis-(4-methoxy-phenyl)-methylene]-tetrahydro-pyran (96835-19-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Mg / 1) ether

2: 0.75 g / KHSO₄ / 1 h / 160 - 170 °C

With potassium hydrogensulfate; magnesium;

upstream raw materials:

Bis-(4-methoxy-phenyl)-(tetrahydro-pyran-4-yl)-methanol

ethyl tetrahydro-2H-pyran-4-carboxylate

1-bromo-4-methoxy-benzene

Downstream raw materials:

C₂₀H₂₂O₄

C₂₀H₂₀Br₂O₄

C₂₀H₂₃FO₄