Technology Process of trclosan glycolic acid stearate
There total 4 articles about trclosan glycolic acid stearate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
triclosan;
With
pyridine;
In
ethyl acetate;
at 20 ℃;
for 10h;
Inert atmosphere;
stearoyloxy-acetyl chloride;
In
ethyl acetate;
at 20 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 24 h / 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 2942.29 Torr
3.1: thionyl chloride / 24 h / Inert atmosphere; Reflux
4.1: pyridine / ethyl acetate / 10 h / 20 °C / Inert atmosphere
4.2: 20 h / 20 °C
With
pyridine; thionyl chloride; hydrogen; triethylamine;
palladium 10% on activated carbon;
In
ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 2942.29 Torr
2.1: thionyl chloride / 24 h / Inert atmosphere; Reflux
3.1: pyridine / ethyl acetate / 10 h / 20 °C / Inert atmosphere
3.2: 20 h / 20 °C
With
pyridine; thionyl chloride; hydrogen;
palladium 10% on activated carbon;
In
ethyl acetate;
