1-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-C-diethylphosphono-3-O-trimethylsilyl-β-D-threo-pentofuranosyl)thymine

Base Information

Chemical Name:1-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-C-diethylphosphono-3-O-trimethylsilyl-β-D-threo-pentofuranosyl)thymine
CAS No.:305820-01-3
Molecular Formula:C₃₃H₄₉N₂O₈PSi₂
Molecular Weight:688.905
Hs Code.:

Synonyms:1-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-C-diethylphosphono-3-O-trimethylsilyl-β-D-threo-pentofuranosyl)thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-C-diethylphosphono-3-O-trimethylsilyl-β-D-threo-pentofuranosyl)thymine

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Technology Process of 1-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-C-diethylphosphono-3-O-trimethylsilyl-β-D-threo-pentofuranosyl)thymine

There total 2 articles about 1-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-C-diethylphosphono-3-O-trimethylsilyl-β-D-threo-pentofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 305819-88-9
5'-O-(tert-butyldiphenylsilyl)-3'-keto-2'-deoxythymidine

: 13716-45-5
diethyl trimethylsilyl phosphite

: 305820-01-3
1-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-C-diethylphosphono-3-O-trimethylsilyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1080/15257770008035038

Reference yield:

: 101527-40-6
5'-O-tert-butyldiphenylsilylthymidine

: 305820-01-3
1-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-C-diethylphosphono-3-O-trimethylsilyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin reagent / CH₂Cl₂ / 0 - 20 °C

2: 83 percent / CH₂Cl₂ / 20 °C

With Dess-Martin periodane; In dichloromethane; 1: Oxidation / 2: Addition;
DOI:10.1080/15257770008035038