5-Cyano-4-ethyl-2-formyl-1H-pyrrole-3-carboxylic acid benzyl ester

Base Information

• Chemical Name: 5-Cyano-4-ethyl-2-formyl-1H-pyrrole-3-carboxylic acid benzyl ester
• CAS No.: 124857-18-7
• Molecular Formula: C₁₆H₁₄N₂O₃
• Molecular Weight: 282.299
• Mol file: 124857-18-7.mol

Synonyms:5-Cyano-4-ethyl-2-formyl-1H-pyrrole-3-carboxylic acid benzyl ester

Chemical Property of 5-Cyano-4-ethyl-2-formyl-1H-pyrrole-3-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 5-Cyano-4-ethyl-2-formyl-1H-pyrrole-3-carboxylic acid benzyl ester

There total 4 articles about 5-Cyano-4-ethyl-2-formyl-1H-pyrrole-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 5-cyano-4-ethyl-2-methylpyrrole-3-carboxylate → 5-Cyano-4-ethyl-2-formyl-1H-pyrrole-3-carboxylic acid benzyl ester (124857-18-7)

Guidance literature:

With sulfuryl dichloride; water; Multistep reaction; 1) AcOH, 50 deg C;

DOI:10.1021/jo00290a022

Reference yield:

4-Ethyl-5-(hydroxyimino-methyl)-2-methyl-1H-pyrrole-3-carboxylic acid benzyl ester → 5-Cyano-4-ethyl-2-formyl-1H-pyrrole-3-carboxylic acid benzyl ester (124857-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Ac₂O / Heating

2: 1) SO₂Cl₂, 2) H₂O / 1) AcOH, 50 deg C

With sulfuryl dichloride; water; acetic anhydride;

DOI:10.1021/jo00290a022

Reference yield:

benzyl 5-formyl-4-ethyl-2-methylpyrrole-3-carboxylate → 5-Cyano-4-ethyl-2-formyl-1H-pyrrole-3-carboxylic acid benzyl ester (124857-18-7)

Guidance literature:

Multi-step reaction with 3 steps

2: Ac₂O / Heating

3: 1) SO₂Cl₂, 2) H₂O / 1) AcOH, 50 deg C

With sulfuryl dichloride; water; acetic anhydride;

DOI:10.1021/jo00290a022

upstream raw materials:

benzyl 4-ethyl-2-methylpyrrole-3-carboxylate

Downstream raw materials:

C₃₃H₂₉N₅O₄

C₂₄H₂₁N₃O₂