(S)-3-{(2R,11R)-2-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-11-[(2R,5R,2'R,5'R)-5'-((R)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-undecyl}-5-methyl-5H-furan-2-one

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Chemical Name:(S)-3-{(2R,11R)-2-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-11-[(2R,5R,2'R,5'R)-5'-((R)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-undecyl}-5-methyl-5H-furan-2-one
CAS No.:173428-01-8
Molecular Formula:C₅₁H₈₀O₇Si
Molecular Weight:833.277
Hs Code.:

(S)-3-{(2R,11R)-2-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-11-[(2R,5R,2'R,5'R)-5'-((R)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-undecyl}-5-methyl-5H-furan-2-one

Synonyms:(S)-3-{(2R,11R)-2-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-11-[(2R,5R,2'R,5'R)-5'-((R)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-undecyl}-5-methyl-5H-furan-2-one

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Chemical Property of (S)-3-{(2R,11R)-2-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-11-[(2R,5R,2'R,5'R)-5'-((R)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-undecyl}-5-methyl-5H-furan-2-one

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Technology Process of (S)-3-{(2R,11R)-2-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-11-[(2R,5R,2'R,5'R)-5'-((R)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-undecyl}-5-methyl-5H-furan-2-one

There total 18 articles about (S)-3-{(2R,11R)-2-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-11-[(2R,5R,2'R,5'R)-5'-((R)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-undecyl}-5-methyl-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 197968-19-7
{2R-[2α[2'R*, 5'R*(R*)],5β],[1(S*), 2R*, 11R*]}-3-{2-[(1,1-dimethylethyl)diphenylsilyloxy]-11-hydroxy-11-[octahydro-5'-(1-hydroxyundec-3-ynyl) [2.2'-bifuran]-5-yl]-6-undecen-8-ynyl}-5-methyl-2-(5H)-furanone

: 173428-01-8
(S)-3-{(2R,11R)-2-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-11-[(2R,5R,2'R,5'R)-5'-((R)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-undecyl}-5-methyl-5H-furan-2-one

Guidance literature:: With Wilkinson's catalyst; hydrogen; In benzene; Ambient temperature;
DOI:10.1021/ja953781q

Reference yield:

: 18922-04-8
6-iodohex-1-ene

: 173428-01-8
(S)-3-{(2R,11R)-2-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-11-[(2R,5R,2'R,5'R)-5'-((R)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-undecyl}-5-methyl-5H-furan-2-one

Guidance literature:: Multi-step reaction with 12 steps

1: 72 percent

2: 62 percent / AD-mix-β

3: 1.) CH(OME)3, PPTS, 2.) AcBr, 3.) K₂CO₃

4: BF₃*Et₂O

5: DMAP

6: PPTS / ethanol

7: 1.) Red-Al, 2.) I₂, 3.) (Ph₃P)2PdCl₂, NH₂NH₂, K₂CO₃

8: CAN / H₂O; acetonitrile

9: 1.) oxalyl chloride, DMSO, 2.) Et₃N

10: CrCl₂ / tetrahydrofuran; dioxane

11: 82 percent / (Ph₃P)2PdCl₂, CuI, Et₃N

12: 71 percent / (Ph₃P)3RhCl, H₂ / benzene / Ambient temperature

With chromium dichloride; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Wilkinson's catalyst; oxalyl dichloride; ammonium cerium(IV) nitrate; Acetyl bromide; AD-mix-β; boron trifluoride diethyl etherate; hydrogen; iodine; pyridinium p-toluenesulfonate; potassium carbonate; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; hydrazine; trimethyl orthoformate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile; benzene;
DOI:10.1021/ja953781q

Reference yield:

: 173427-88-8
(-)-(2R,3R,6R,7R,10R,11R)-1,2:3,6:7,10:11,12-tetraepoxydodecane

: 173428-01-8
(S)-3-{(2R,11R)-2-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-11-[(2R,5R,2'R,5'R)-5'-((R)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-undecyl}-5-methyl-5H-furan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: BF₃*OEt₂

2: BF₃*OEt₂

3: K₂CO₃ / methanol

4: 82 percent / (Ph₃P)2PdCl₂, CuI, Et₃N

5: 71 percent / (Ph₃P)3RhCl, H₂ / benzene / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Wilkinson's catalyst; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; triethylamine; In methanol; benzene;
DOI:10.1021/ja953781q