(4S,5S)-4,5-di(2-bromobenzyl)-1-tert-butoxycarbonyl-2-imidazolidinone

Base Information

Chemical Name:(4S,5S)-4,5-di(2-bromobenzyl)-1-tert-butoxycarbonyl-2-imidazolidinone
CAS No.:1262794-27-3
Molecular Formula:C₂₂H₂₄Br₂N₂O₃
Molecular Weight:524.252
Hs Code.:

Synonyms:(4S,5S)-4,5-di(2-bromobenzyl)-1-tert-butoxycarbonyl-2-imidazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-4,5-di(2-bromobenzyl)-1-tert-butoxycarbonyl-2-imidazolidinone

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Technology Process of (4S,5S)-4,5-di(2-bromobenzyl)-1-tert-butoxycarbonyl-2-imidazolidinone

There total 2 articles about (4S,5S)-4,5-di(2-bromobenzyl)-1-tert-butoxycarbonyl-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 745038-82-8
(2-bromophenyl)magnesium chloride

: 617711-69-0
(2S,2′S)-1,1′-di(tert-butoxycarbonyl)-2,2′-biaziridine

: 1262794-27-3
(4S,5S)-4,5-di(2-bromobenzyl)-1-tert-butoxycarbonyl-2-imidazolidinone

: 1262794-28-4
(2S,3S)-1,4-di(2-bromophenyl)-2,3-di(N-tert-butoxycarbonylamino)butane

Guidance literature:: With CuBr_.SMe₂; In tetrahydrofuran; at -40 - 20 ℃; for 16h; enantiospecific reaction; Inert atmosphere;
DOI:10.1021/acs.joc.5b00832

Reference yield:

: 583-55-1
1-Bromo-2-iodobenzene

: 1262794-27-3
(4S,5S)-4,5-di(2-bromobenzyl)-1-tert-butoxycarbonyl-2-imidazolidinone

: 1262794-28-4
(2S,3S)-1,4-di(2-bromophenyl)-2,3-di(N-tert-butoxycarbonylamino)butane

Guidance literature:: Multi-step reaction with 2 steps

1: isopropylmagnesium chloride

2: CuBr_.SMe₂ / tetrahydrofuran / 16 h / -40 - 20 °C / Inert atmosphere

With isopropylmagnesium chloride; In tetrahydrofuran;
DOI:10.1021/acs.joc.5b00832

Reference yield: 89.0%

: 1262794-27-3
(4S,5S)-4,5-di(2-bromobenzyl)-1-tert-butoxycarbonyl-2-imidazolidinone

: 1262794-26-2
(2S,3S)-1,4-bis(2-bromophenyl)butane-2,3-diamine

Guidance literature:: (4S,5S)-4,5-di(2-bromobenzyl)-1-tert-butoxycarbonyl-2-imidazolidinone; With hydrogenchloride; In water; at 110 ℃; for 12h; Microwave irradiation;

With water; sodium hydroxide; In dichloromethane;
DOI:10.1039/c0cc04045b