4-Methylisoquinoline-5-sulfonyl chloride

Base Information

Chemical Name:4-Methylisoquinoline-5-sulfonyl chloride
CAS No.:194032-16-1
Molecular Formula:C10H8ClNO2S
Molecular Weight:241.698
Hs Code.:
European Community (EC) Number:855-242-7
DSSTox Substance ID:DTXSID20573241
Wikidata:Q82461875
Mol file:194032-16-1.mol

Synonyms:194032-16-1;4-Methylisoquinoline-5-sulfonyl chloride;5-CHLOROSULFONYL-4-METHYLISOQUINOLINE;4-Methyl-5-isoquinolinesulfonyl Chloride;SCHEMBL2000333;DTXSID20573241;JHXVHTVZWRBEBJ-UHFFFAOYSA-N;5-chlorosulfonyl-4-methyl-isoquinoline;AKOS006221399;4-Methylisoquinoline-5-sulfonylchloride;AM803449;CS-0215665;EN300-272536;A919590;J-012566;J-515787

Suppliers and Price of 4-Methylisoquinoline-5-sulfonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Chlorosulfonyl-4-methylisoquinoline
100mg
$ 475.00

Crysdot
4-Methylisoquinoline-5-sulfonylchloride 97%
1g
$ 605.00

Biosynth Carbosynth
5-Chlorosulfonyl-4-methylisoquinoline
50 mg
$ 413.50

Biosynth Carbosynth
5-Chlorosulfonyl-4-methylisoquinoline
25 mg
$ 227.50

Biosynth Carbosynth
5-Chlorosulfonyl-4-methylisoquinoline
10 mg
$ 125.10

Biosynth Carbosynth
5-Chlorosulfonyl-4-methylisoquinoline
100 mg
$ 751.00

American Custom Chemicals Corporation
5-CHLOROSULFONYL-4-METHYLISOQUINOLINE 95.00%
25MG
$ 721.88

American Custom Chemicals Corporation
5-CHLOROSULFONYL-4-METHYLISOQUINOLINE 95.00%
250MG
$ 1732.50

Alichem
4-Methylisoquinoline-5-sulfonylchloride
5g
$ 1568.70

Alichem
4-Methylisoquinoline-5-sulfonylchloride
1g
$ 512.94

Total 9 raw suppliers

Chemical Property of 4-Methylisoquinoline-5-sulfonyl chloride

Chemical Property:

Appearance/Colour:Light Yellow to Tan Solid
Vapor Pressure:7E-06mmHg at 25°C
Melting Point:113-118 °C
Refractive Index:1.63
Boiling Point:388.141 °C at 760 mmHg
PKA:3.52±0.14(Predicted)
Flash Point:188.541 °C
PSA：55.41000
Density:1.424 g/cm³
LogP:3.55150
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:Acetone, Chloroform, Dichloromethane, Ether, Ethyl Acetate, Methanol
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:240.9964274
Heavy Atom Count:15
Complexity:325

Purity/Quality:

97% ^*data from raw suppliers

5-Chlorosulfonyl-4-methylisoquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CN=CC2=C1C(=CC=C2)S(=O)(=O)Cl
Uses 5-Chlorosulfonyl-4-methylisoquinoline (cas# 194032-16-1) is a compound useful in organic synthesis.

Technology Process of 4-Methylisoquinoline-5-sulfonyl chloride

There total 5 articles about 4-Methylisoquinoline-5-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 194032-18-3
4-methylisoquinolin-5-amine

: 194032-16-1
4-methyl-5-isoquinolinesulfonyl chloride

Guidance literature:: 4-methylisoquinolin-5-amine; With hydrogenchloride; sodium nitrite; In water; at -5 ℃; for 1h; Inert atmosphere;

With sulfur dioxide; acetic acid; copper(l) chloride; In water; at 0 - 25 ℃; for 2h; Inert atmosphere;

Reference yield:

cupric chloride: cupric chloride

: 194032-18-3
4-methylisoquinolin-5-amine

: 194032-16-1
4-methyl-5-isoquinolinesulfonyl chloride

Guidance literature:: With hydrogenchloride; sodium chloride; sulphurous acid; sodium hydrogencarbonate; acetic acid; sodium nitrite; In water;

Reference yield:

: 1532-97-4
4-bromoisoquinoline

: 194032-16-1
4-methyl-5-isoquinolinesulfonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; potassium nitrate / 12 h / 0 - 25 °C / Inert atmosphere

2.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 12 h / 110 °C

3.1: zinc; ammonium chloride / water; tetrahydrofuran / 12 h / 25 °C

4.1: hydrogenchloride; sodium nitrite / water / 1 h / -5 °C / Inert atmosphere

4.2: 2 h / 0 - 25 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; ammonium chloride; caesium carbonate; potassium nitrate; zinc; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; water;