{1-[(1,3-thiazol-2-ylthio)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate

Base Information

Chemical Name:{1-[(1,3-thiazol-2-ylthio)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate
CAS No.:787604-45-9
Molecular Formula:C₂₅H₃₅N₃O₄S₂
Molecular Weight:505.703
Hs Code.:

Synonyms:{1-[(1,3-thiazol-2-ylthio)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate

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Chemical Property of {1-[(1,3-thiazol-2-ylthio)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate

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Technology Process of {1-[(1,3-thiazol-2-ylthio)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate

There total 5 articles about {1-[(1,3-thiazol-2-ylthio)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 497946-74-4
(3S)-3-amino-2-hydroxy-N-[(1R)-1-phenylethyl]heptanamide

: C₁₀H₁₂ClNO₂S₂

: 787604-45-9
{1-[(1,3-thiazol-2-ylthio)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 6h;
DOI:10.1021/jm040107n

Reference yield:

: 4415-73-0
[1-(hydroxymethyl)cyclobutyl]methanol

: 787604-45-9
{1-[(1,3-thiazol-2-ylthio)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: PPh₃; di-tert-butylazodicarboxylate / CH₂Cl₂ / 0.08 h / 20 °C

1.2: CH₂Cl₂ / 2 h / 20 °C

2.1: CH₂Cl₂; toluene / 16 h / 0 °C

3.1: N,N-diisopropylethylamine / tetrahydrofuran / 6 h / 0 °C

With di-tert-butyl-diazodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene; 1.2: Mitsunobu reaction;
DOI:10.1021/jm040107n

Reference yield:

: 3779-29-1
diethyl cyclobutane-1,1-dicarboxylate

: 787604-45-9
{1-[(1,3-thiazol-2-ylthio)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / 3 h / 20 °C

2.1: PPh₃; di-tert-butylazodicarboxylate / CH₂Cl₂ / 0.08 h / 20 °C

2.2: CH₂Cl₂ / 2 h / 20 °C

3.1: CH₂Cl₂; toluene / 16 h / 0 °C

4.1: N,N-diisopropylethylamine / tetrahydrofuran / 6 h / 0 °C

With lithium aluminium tetrahydride; di-tert-butyl-diazodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 2.2: Mitsunobu reaction;
DOI:10.1021/jm040107n