(S)-ethyl 2-(1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazole-4-carboxylate

Base Information

• Chemical Name: (S)-ethyl 2-(1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazole-4-carboxylate
• CAS No.: 131148-64-6
• Molecular Formula: C₁₉H₂₄N₂O₄S
• Molecular Weight: 376.477
• Mol file: 131148-64-6.mol

Synonyms:(S)-ethyl 2-(1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazole-4-carboxylate

Chemical Property of (S)-ethyl 2-(1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-ethyl 2-(1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazole-4-carboxylate

There total 14 articles about (S)-ethyl 2-(1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(S)-2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-4,5-dihydro-thiazole-4-carboxylic acid ethyl ester → (S)-ethyl 2-(1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazole-4-carboxylate (131148-64-6)

Guidance literature:

With copper diacetate; tert-Butyl peroxybenzoate; copper(I) bromide; In benzene; for 4.5h; Heating;

DOI:10.1021/jo9613491

Reference yield: 50.0%

(R)-2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazolidine-4-carboxylic acid ethyl ester (218288-92-7) → (S)-ethyl 2-(1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazole-4-carboxylate (131148-64-6)

Guidance literature:

With manganese(IV) oxide;

DOI:10.1016/S0960-894X(98)00511-3

Reference yield: 39.0%

ethyl Bromopyruvate (70-23-5) + tert-butyl [(2S)-1-amino-3-phenyl-1-thioxopropan-2-yl]carbamate (99281-95-5) → (S)-ethyl 2-(1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazole-4-carboxylate (131148-64-6)

Guidance literature:

In diethyl ether; for 48h; Ambient temperature;

DOI:10.1021/jo00215a040

upstream raw materials:

ethyl Bromopyruvate

tert-butyl [(2S)-1-amino-3-phenyl-1-thioxopropan-2-yl]carbamate

(R)-2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazolidine-4-carboxylic acid ethyl ester

L-cystein ethyl ester

Downstream raw materials:

EtO-Thiazole-Phe-NH₂

EtO-Thiazole-Phe-Val-NHBoc

San B 7

(S)-2-(1-amino-2-(4-methoxyphenyl)ethyl)thiazole-4-carboxylic acid 2,2,2-trifluoroacetate salt