1-benzyl-4-(4-fluorophenyl)-5-methyl-pyrazole-3-carboxylic acid ethyl ester

Base Information

Chemical Name:1-benzyl-4-(4-fluorophenyl)-5-methyl-pyrazole-3-carboxylic acid ethyl ester
CAS No.:1341198-44-4
Molecular Formula:C₂₀H₁₉FN₂O₂
Molecular Weight:338.381
Hs Code.:

Synonyms:1-benzyl-4-(4-fluorophenyl)-5-methyl-pyrazole-3-carboxylic acid ethyl ester

Suppliers and Price of 1-benzyl-4-(4-fluorophenyl)-5-methyl-pyrazole-3-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-benzyl-4-(4-fluorophenyl)-5-methyl-pyrazole-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-(4-fluorophenyl)-5-methyl-pyrazole-3-carboxylic acid ethyl ester

There total 6 articles about 1-benzyl-4-(4-fluorophenyl)-5-methyl-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1341198-43-3
1-benzyl-4-iodo-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1765-93-1
4-fluoroboronic acid

: 1341198-44-4
1-benzyl-4-(4-fluorophenyl)-5-methyl-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ml2001938

Reference yield:

: 4027-57-0
ethyl 5-methyl-2H-pyrazole-3-carboxylate

: 1341198-44-4
1-benzyl-4-(4-fluorophenyl)-5-methyl-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine / acetonitrile / 4 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 6 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/ml2001938

Reference yield:

: 1384129-06-9
C₂₀H₁₉BrN₂O₂

: 1341198-44-4
1-benzyl-4-(4-fluorophenyl)-5-methyl-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; fluoroboronic acid; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 12h;
DOI:10.1016/j.bmcl.2012.05.020