4-(2-bromo-4,5-dimethoxyphenethyl)-7-(tetrahydro-2H-pyran-2-yl)-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione

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Chemical Name:4-(2-bromo-4,5-dimethoxyphenethyl)-7-(tetrahydro-2H-pyran-2-yl)-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione
CAS No.:911842-52-9
Molecular Formula:C₂₁H₂₄BrN₃O₆
Molecular Weight:494.342
Hs Code.:

Synonyms:4-(2-bromo-4,5-dimethoxyphenethyl)-7-(tetrahydro-2H-pyran-2-yl)-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione

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Chemical Property of 4-(2-bromo-4,5-dimethoxyphenethyl)-7-(tetrahydro-2H-pyran-2-yl)-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione

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Technology Process of 4-(2-bromo-4,5-dimethoxyphenethyl)-7-(tetrahydro-2H-pyran-2-yl)-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione

There total 5 articles about 4-(2-bromo-4,5-dimethoxyphenethyl)-7-(tetrahydro-2H-pyran-2-yl)-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.2%

: 645405-25-0
4-(3,4-dimethoxyphenethyl)-7-(tetrahydro-2H-pyran-2-yl)-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione

: 911842-52-9
4-(2-bromo-4,5-dimethoxyphenethyl)-7-(tetrahydro-2H-pyran-2-yl)-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1016/j.tet.2006.07.009

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 911842-52-9
4-(2-bromo-4,5-dimethoxyphenethyl)-7-(tetrahydro-2H-pyran-2-yl)-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: p-toluenesulfonic acid monohydrate / tetrahydrofuran / 29 h / Heating

2: potassium hydroxide / 3 h / 20 °C

3: 86.5 percent / aq. potassium hydroxide / 3 h / Heating

4: 83.7 percent / cesium carbonate / acetonitrile / 60 h / Heating

5: 82.2 percent / NBS / dimethylformamide / 48 h / 20 °C

With potassium hydroxide; N-Bromosuccinimide; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 4: Smiles rearrangement;
DOI:10.1016/j.tet.2006.07.009

Reference yield:

: 173206-13-8
4,5-dichloro-2-(tetrahydro-2H-pyran-2-yl)-3(2H)-pyridazinone

: 911842-52-9
4-(2-bromo-4,5-dimethoxyphenethyl)-7-(tetrahydro-2H-pyran-2-yl)-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / 3 h / 20 °C

2: 86.5 percent / aq. potassium hydroxide / 3 h / Heating

3: 83.7 percent / cesium carbonate / acetonitrile / 60 h / Heating

4: 82.2 percent / NBS / dimethylformamide / 48 h / 20 °C

With potassium hydroxide; N-Bromosuccinimide; caesium carbonate; In N,N-dimethyl-formamide; acetonitrile; 3: Smiles rearrangement;
DOI:10.1016/j.tet.2006.07.009