24-[bis[5'-chloro-4'-methoxy-3'-(carboxy)phenyl]methylene]-3α,7α,12α-trihydroxycholane

Base Information

Chemical Name:24-[bis[5'-chloro-4'-methoxy-3'-(carboxy)phenyl]methylene]-3α,7α,12α-trihydroxycholane
CAS No.:397843-07-1
Molecular Formula:C₄₁H₅₂Cl₂O₉
Molecular Weight:759.764
Hs Code.:

Synonyms:24-[bis[5'-chloro-4'-methoxy-3'-(carboxy)phenyl]methylene]-3α,7α,12α-trihydroxycholane

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Chemical Property of 24-[bis[5'-chloro-4'-methoxy-3'-(carboxy)phenyl]methylene]-3α,7α,12α-trihydroxycholane

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Technology Process of 24-[bis[5'-chloro-4'-methoxy-3'-(carboxy)phenyl]methylene]-3α,7α,12α-trihydroxycholane

There total 3 articles about 24-[bis[5'-chloro-4'-methoxy-3'-(carboxy)phenyl]methylene]-3α,7α,12α-trihydroxycholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 397843-06-0
24-[bis[5'-chloro-4'-methoxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane

: 397843-07-1
24-[bis[5'-chloro-4'-methoxy-3'-(carboxy)phenyl]methylene]-3α,7α,12α-trihydroxycholane

Guidance literature:: With potassium hydroxide; In methanol; for 24h; Heating;
DOI:10.1016/S0040-4020(01)00955-3

Reference yield:

: 87899-19-2
(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-((R)-5-oxopentan-2-yl)hexadecahydro-1H-cyclopenta[a] phenanthrene-3,7,12-triyl triacetate

: 397843-07-1
24-[bis[5'-chloro-4'-methoxy-3'-(carboxy)phenyl]methylene]-3α,7α,12α-trihydroxycholane

Guidance literature:: Multi-step reaction with 2 steps

1: 25 percent / TiCl₄*2THF; Zn dust / tetrahydrofuran / 12 h / Heating

2: 90 percent / KOH / methanol / 24 h / Heating

With potassium hydroxide; tetrachlorobis(tetrahydrofuran)titanium(IV); zinc; In tetrahydrofuran; methanol; 1: McMurry coupling;
DOI:10.1016/S0040-4020(01)00955-3

Reference yield:

: 20171-56-6
3α,7α,12α-triacetoxy-5β-cholane-24-ol

: 397843-07-1
24-[bis[5'-chloro-4'-methoxy-3'-(carboxy)phenyl]methylene]-3α,7α,12α-trihydroxycholane

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h

2: 25 percent / TiCl₄*2THF; Zn dust / tetrahydrofuran / 12 h / Heating

3: 90 percent / KOH / methanol / 24 h / Heating

With potassium hydroxide; tetrachlorobis(tetrahydrofuran)titanium(IV); Dess-Martin periodane; zinc; In tetrahydrofuran; methanol; dichloromethane; 2: McMurry coupling;
DOI:10.1016/S0040-4020(01)00955-3