2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 2-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-1-methyl-ethyl ester

Base Information

Chemical Name:2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 2-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-1-methyl-ethyl ester
CAS No.:1026048-75-8
Molecular Formula:C₂₆H₃₄ClNO₁₁
Molecular Weight:572.009
Hs Code.:

Synonyms:2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 2-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-1-methyl-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 2-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-1-methyl-ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 2-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-1-methyl-ethyl ester

There total 10 articles about 2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 2-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913622-96-5
5-(2-chloro-3,5-dihydroxy-6-((1-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propan-2-yloxy)carbonyl)phenyl)pentanoic acid

: 1026048-75-8
2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 2-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-1-methyl-ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h;
DOI:10.1021/jo061054f

Reference yield:

: 854261-02-2
1-(2-methoxy-3,6-bis(methoxymethoxy)phenyl)propan-2-ol

: 1026048-75-8
2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 2-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: NH₄NO₃; (CF₃CO)2O / acetonitrile / 0.25 h / 20 °C

1.2: LiOH / tetrahydrofuran; methanol; H₂O / 0.08 h

2.1: 68 percent / DCC; DMAP / tetrahydrofuran / 10 h / 20 - 50 °C

3.1: OsO₄; NaIO₄; 2,6-lutidine / dioxane; H₂O / 2 h / 20 °C

4.1: 200 mg / 2-methyl-2-butene; NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

5.1: H₂ / Pd/C / ethanol / 3 h

With ammonium nitrate; 2,6-dimethylpyridine; dmap; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo061054f

Reference yield:

: 854261-03-3
1-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propan-2-ol

: 1026048-75-8
2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 2-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / DCC; DMAP / tetrahydrofuran / 10 h / 20 - 50 °C

2: OsO₄; NaIO₄; 2,6-lutidine / dioxane; H₂O / 2 h / 20 °C

3: 200 mg / 2-methyl-2-butene; NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

4: H₂ / Pd/C / ethanol / 3 h

With 2,6-dimethylpyridine; dmap; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; tert-butyl alcohol;
DOI:10.1021/jo061054f