(4R,5S,6R)-2-{(S)-3-[(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butyl}-6-(tert-butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile

Base Information

Chemical Name:(4R,5S,6R)-2-{(S)-3-[(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butyl}-6-(tert-butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile
CAS No.:913355-81-4
Molecular Formula:C₅₁H₇₇ClN₂O₆Si₃
Molecular Weight:933.892
Hs Code.:

(4R,5S,6R)-2-{(S)-3-[(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butyl}-6-(tert-butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile

Synonyms:(4R,5S,6R)-2-{(S)-3-[(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butyl}-6-(tert-butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile

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Chemical Property of (4R,5S,6R)-2-{(S)-3-[(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butyl}-6-(tert-butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile

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Technology Process of (4R,5S,6R)-2-{(S)-3-[(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butyl}-6-(tert-butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile

There total 16 articles about (4R,5S,6R)-2-{(S)-3-[(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butyl}-6-(tert-butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913355-73-4
(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazole

: 913355-79-0
(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile

: 913355-81-4
(4R,5S,6R)-2-{(S)-3-[(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butyl}-6-(tert-butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile

Guidance literature:: (4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazole; In tetrahydrofuran;
DOI:10.1002/anie.200601655

Reference yield:

: 865872-30-6
tert-butyl-((3R,4R)-4-chloro-3-methoxyhex-5-enyloxy)dimethylsilane

: 913355-81-4
(4R,5S,6R)-2-{(S)-3-[(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butyl}-6-(tert-butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: K₃[Fe(CN)6]; hydroquinine 2,5-diphenyl-4,6-pyrimidinediyl diether; OsO₄ / 2-methyl-propan-2-ol; H₂O

2.1: pyridine

3.1: potassium carbonate / methanol

4.1: nBuLi / tetrahydrofuran / 0 °C

4.2: tetrahydrofuran / 0 °C

5.1: imidazole

6.1: pyridinium para-toluenesulfonate / methanol

7.1: dimethylsulfoxide; oxalyl chloride; triethylamine / CH₂Cl₂ / -78 - 20 °C

8.1: N-methylmorpholine-N-oxide / CH₂Cl₂

9.1: lithium diisopropylamide / tetrahydrofuran / -78 °C

9.2: tetrahydrofuran

With pyridine; 1H-imidazole; osmium(VIII) oxide; n-butyllithium; oxalyl dichloride; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); pyridinium p-toluenesulfonate; potassium carbonate; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; potassium hexacyanoferrate(III); lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; 7.1: Swern oxidation;
DOI:10.1002/anie.200601655

Reference yield:

: 865872-31-7
(2R,3R,4R)-6-(tert-butyldimethylsilanyloxy)-3-chloro-4-methoxyhexane-1,2-diol

: 913355-81-4
(4R,5S,6R)-2-{(S)-3-[(S)-5-((S)-3-Benzyloxy-1-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butyl}-6-(tert-butyl-diphenyl-silanyloxy)-5-chloro-4-methoxy-2-trimethylsilanyloxy-oct-7-enenitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine

2.1: potassium carbonate / methanol

3.1: nBuLi / tetrahydrofuran / 0 °C

3.2: tetrahydrofuran / 0 °C

4.1: imidazole

5.1: pyridinium para-toluenesulfonate / methanol

6.1: dimethylsulfoxide; oxalyl chloride; triethylamine / CH₂Cl₂ / -78 - 20 °C

7.1: N-methylmorpholine-N-oxide / CH₂Cl₂

8.1: lithium diisopropylamide / tetrahydrofuran / -78 °C

8.2: tetrahydrofuran

With pyridine; 1H-imidazole; n-butyllithium; oxalyl dichloride; pyridinium p-toluenesulfonate; potassium carbonate; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; 6.1: Swern oxidation;
DOI:10.1002/anie.200601655