Technology Process of 6-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid-phenylamide
There total 12 articles about 6-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid-phenylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid / dichloromethane / 0 °C / Inert atmosphere
1.2: 0.33 h
2.1: hydrogen / 5% rhodium-on-charcoal / methanol / 3 h / 20 °C / 2250.23 Torr
3.1: N,N-dimethyl-formamide / 2 h / 100 °C
4.1: hydrogen / palladium 10% on activated carbon / methanol / 50 °C / 2250.23 Torr
5.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; N,N-dimethyl-formamide; CAD / 3 h / 20 °C
6.1: sodium hydroxide; water / tetrahydrofuran / 20 °C
6.2: 20 °C
7.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C
With
water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
5% rhodium-on-charcoal; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; CAD; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N,N-dimethyl-formamide / 2 h / 100 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 50 °C / 2250.23 Torr
3.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; N,N-dimethyl-formamide; CAD / 3 h / 20 °C
4.1: sodium hydroxide; water / tetrahydrofuran / 20 °C
4.2: 20 °C
5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C
With
water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; CAD; ethyl acetate; N,N-dimethyl-formamide;