2-bromo-4-(4-methoxyphenylsulfonyl)-4,5-dihydrothieno[3,2-c]isoquinoline

Base Information

Chemical Name:2-bromo-4-(4-methoxyphenylsulfonyl)-4,5-dihydrothieno[3,2-c]isoquinoline
CAS No.:1629164-93-7
Molecular Formula:C₁₈H₁₄BrNO₃S₂
Molecular Weight:436.35
Hs Code.:

Synonyms:2-bromo-4-(4-methoxyphenylsulfonyl)-4,5-dihydrothieno[3,2-c]isoquinoline

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Chemical Property of 2-bromo-4-(4-methoxyphenylsulfonyl)-4,5-dihydrothieno[3,2-c]isoquinoline

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Technology Process of 2-bromo-4-(4-methoxyphenylsulfonyl)-4,5-dihydrothieno[3,2-c]isoquinoline

There total 4 articles about 2-bromo-4-(4-methoxyphenylsulfonyl)-4,5-dihydrothieno[3,2-c]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1629165-03-2
4-(4-methoxyphenylsulfonyl)-4,5-dihydrothieno[3,2-c]isoquinoline

: 1629164-93-7
2-bromo-4-(4-methoxyphenylsulfonyl)-4,5-dihydrothieno[3,2-c]isoquinoline

Guidance literature:: With N-Bromosuccinimide; acetic acid; In chloroform; at -5 - 60 ℃; for 16h; Sealed tube; Inert atmosphere;
DOI:10.1016/j.bmcl.2021.128327

Reference yield:

: 1374831-20-5
methyl 3-((N-(2-bromobenzyl)-4-methoxyphenyl)sulfonamido)thiophene-2-carboxylate

: 1629164-93-7
2-bromo-4-(4-methoxyphenylsulfonyl)-4,5-dihydrothieno[3,2-c]isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 85 °C / Sealed tube; Inert atmosphere

2: tri tert-butylphosphoniumtetrafluoroborate; palladium dichloride; caesium carbonate / N,N-dimethyl-formamide / 0.13 h / 170 °C / Microwave irradiation; Sealed tube; Inert atmosphere

3: N-Bromosuccinimide; acetic acid / chloroform / 16 h / -5 - 60 °C / Sealed tube; Inert atmosphere

With N-Bromosuccinimide; water; caesium carbonate; acetic acid; sodium hydroxide; palladium dichloride; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2021.128327

Reference yield:

: 1629164-97-1
C₁₉H₁₆BrNO₅S₂

: 1629164-93-7
2-bromo-4-(4-methoxyphenylsulfonyl)-4,5-dihydrothieno[3,2-c]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: tri tert-butylphosphoniumtetrafluoroborate; palladium dichloride; caesium carbonate / N,N-dimethyl-formamide / 0.13 h / 170 °C / Microwave irradiation; Sealed tube; Inert atmosphere

2: N-Bromosuccinimide; acetic acid / chloroform / 16 h / -5 - 60 °C / Sealed tube; Inert atmosphere

With N-Bromosuccinimide; caesium carbonate; acetic acid; palladium dichloride; tri tert-butylphosphoniumtetrafluoroborate; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2021.128327