4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

Base Information

Chemical Name:4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide
CAS No.:1093395-72-2
Molecular Formula:C₂₉H₂₇F₃N₆O₂
Molecular Weight:548.568
Hs Code.:

Synonyms:4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

There total 8 articles about 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1093395-74-4
C₁₁H₁₅F₃N₄

: 1093395-73-3
lithium 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoate

: 1093395-72-2
4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

Guidance literature:: lithium 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoate; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; for 1h; Heating;

C₁₁H₁₅F₃N₄; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1689-84-5
Bromoxynil

: 1093395-72-2
4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; sodium nitrite

2: iron(III) chloride hexahydrate; hydrazine

3: toluene-4-sulfonic acid / toluene / 110 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol

6: water; lithium hydroxide / tetrahydrofuran; methanol

7: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; iron(III) chloride hexahydrate; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; hydrazine; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.11.090

Reference yield:

: 862730-24-3
3-amino-5-bromo-4-hydroxybenzonitrile

: 1093395-72-2
4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 110 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol

4: water; lithium hydroxide / tetrahydrofuran; methanol

5: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.11.090