1-[6-(diphenylphosphanyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]isoquinoline

Base Information

Chemical Name:1-[6-(diphenylphosphanyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]isoquinoline
CAS No.:1271994-28-5
Molecular Formula:C₃₈H₃₃N₂O₂PS
Molecular Weight:612.732
Hs Code.:

Synonyms:1-[6-(diphenylphosphanyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]isoquinoline

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Chemical Property of 1-[6-(diphenylphosphanyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]isoquinoline

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Technology Process of 1-[6-(diphenylphosphanyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]isoquinoline

There total 4 articles about 1-[6-(diphenylphosphanyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: (+)-1-[6-(diphenylphosphinoyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]isoquinoline

: 1271994-28-5
1-[6-(diphenylphosphanyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]isoquinoline

Guidance literature:: With trichlorosilane; triethylamine; In toluene; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1002/chem.201003134

Reference yield:

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 1271994-28-5
1-[6-(diphenylphosphanyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; triethylamine / toluene / 18 h / 20 °C / Inert atmosphere

2: dihydrogen peroxide / dichloromethane; water / 5 h / 0 - 20 °C

3: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-Solphos / dichloromethane / 16 h / 20 - 80 °C / Inert atmosphere

4: trichlorosilane; triethylamine / toluene / 16 h / 80 °C / Inert atmosphere

With copper(l) iodide; (R)-Solphos; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; trichlorosilane; dihydrogen peroxide; triethylamine; In dichloromethane; water; toluene;
DOI:10.1002/chem.201003134

Reference yield:

: 1271994-34-3
1-[(diphenylphosphanyl)ethynyl]isoquinoline

: 1271994-28-5
1-[6-(diphenylphosphanyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: dihydrogen peroxide / dichloromethane; water / 5 h / 0 - 20 °C

2: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-Solphos / dichloromethane / 16 h / 20 - 80 °C / Inert atmosphere

3: trichlorosilane; triethylamine / toluene / 16 h / 80 °C / Inert atmosphere

With (R)-Solphos; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; trichlorosilane; dihydrogen peroxide; triethylamine; In dichloromethane; water; toluene;
DOI:10.1002/chem.201003134