N₆,N₆-Dibenzyl-N₁,N₁-di-tert-butoxycarbonyl-8-fluoroisoquinoline-1,6-diamine

Base Information

Chemical Name:N₆,N₆-Dibenzyl-N₁,N₁-di-tert-butoxycarbonyl-8-fluoroisoquinoline-1,6-diamine
CAS No.:918811-53-7
Molecular Formula:C₃₃H₃₆FN₃O₄
Molecular Weight:557.665
Hs Code.:

N<sub>6</sub>,N<sub>6</sub>-Dibenzyl-N<sub>1</sub>,N<sub>1</sub>-di-tert-butoxycarbonyl-8-fluoroisoquinoline-1,6-diamine

Synonyms:N₆,N₆-Dibenzyl-N₁,N₁-di-tert-butoxycarbonyl-8-fluoroisoquinoline-1,6-diamine

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Chemical Property of N₆,N₆-Dibenzyl-N₁,N₁-di-tert-butoxycarbonyl-8-fluoroisoquinoline-1,6-diamine

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Technology Process of N₆,N₆-Dibenzyl-N₁,N₁-di-tert-butoxycarbonyl-8-fluoroisoquinoline-1,6-diamine

There total 3 articles about N₆,N₆-Dibenzyl-N₁,N₁-di-tert-butoxycarbonyl-8-fluoroisoquinoline-1,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 918811-52-6
N⁶,N⁶-dibenzyl-8-fluoroisoquinoline-1,6-diamine

: 24424-99-5
di-tert-butyl dicarbonate

: 918811-53-7
N₆,N₆-Dibenzyl-N₁,N₁-di-tert-butoxycarbonyl-8-fluoroisoquinoline-1,6-diamine

Guidance literature:: With dmap; In acetonitrile; at 20 ℃;

Reference yield:

: 918811-51-5
6-(Dibenzylamino)-8-fluoroisoquinolin-1(2H)-one

: 918811-53-7
N₆,N₆-Dibenzyl-N₁,N₁-di-tert-butoxycarbonyl-8-fluoroisoquinoline-1,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 1 h / 100 °C / Inert atmosphere

2: ammonia / ethylene glycol / 130 °C / Autoclave

3: dmap / acetonitrile / 20 °C / Inert atmosphere

With dmap; ammonia; trichlorophosphate; In ethylene glycol; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00469

Reference yield:

: 943740-62-3
1-chloro-6-(dibenzylamino)-8-fluoroisoquinoline

: 918811-53-7
N₆,N₆-Dibenzyl-N₁,N₁-di-tert-butoxycarbonyl-8-fluoroisoquinoline-1,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / ethylene glycol / 130 °C / Autoclave

2: dmap / acetonitrile / 20 °C / Inert atmosphere

With dmap; ammonia; In ethylene glycol; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00469