(2S)-2-<(4S,5S)-5-Ethyl-2,2-dimethyl-1,3-dioxan-4-yl>propyl phenyl sulfone

Base Information

Chemical Name:(2S)-2-<(4S,5S)-5-Ethyl-2,2-dimethyl-1,3-dioxan-4-yl>propyl phenyl sulfone
CAS No.:131967-58-3
Molecular Formula:C₁₇H₂₆O₄S
Molecular Weight:326.457
Hs Code.:

Synonyms:(2S)-2-<(4S,5S)-5-Ethyl-2,2-dimethyl-1,3-dioxan-4-yl>propyl phenyl sulfone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-<(4S,5S)-5-Ethyl-2,2-dimethyl-1,3-dioxan-4-yl>propyl phenyl sulfone

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Technology Process of (2S)-2-<(4S,5S)-5-Ethyl-2,2-dimethyl-1,3-dioxan-4-yl>propyl phenyl sulfone

There total 19 articles about (2S)-2-<(4S,5S)-5-Ethyl-2,2-dimethyl-1,3-dioxan-4-yl>propyl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 873-55-2
sodium benzenesulfonate

: 144534-92-9
(4R,5S)-5-Ethyl-4-((R)-2-iodo-1-methyl-ethyl)-2,2-dimethyl-[1,3]dioxane

: 131967-58-3
(2S)-2-<(4S,5S)-5-Ethyl-2,2-dimethyl-1,3-dioxan-4-yl>propyl phenyl sulfone

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1248/cpb.41.2044

Reference yield:

: 110653-58-2
(2R,3R,4S)-4-benzyloxymethyl-3-formyloxy-2-methylhexanal

: 131967-58-3
(2S)-2-<(4S,5S)-5-Ethyl-2,2-dimethyl-1,3-dioxan-4-yl>propyl phenyl sulfone

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / LiAlH₄ / diethyl ether / 0.08 h / 0 deg C to r.t.

2: 98 percent / pyridine / Ambient temperature

3: 100 percent / H₂ / 5percent Pd/C / ethyl acetate / 6 h / Ambient temperature

4: 98 percent / d-camphorsulfonic acid / benzene / 0.5 h / Ambient temperature

5: 96 percent / LiAlH₄ / diethyl ether / 1 h / 0 deg C to r.t.

6: 96 percent / pyridine / 2 h / Ambient temperature

7: 94 percent / NaI / acetone / 8 h / Heating

8: 93 percent / dimethylformamide / 6 h / 60 °C

With pyridine; lithium aluminium tetrahydride; (1S)-10-camphorsulfonic acid; hydrogen; sodium iodide; palladium on activated charcoal; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1016/S0040-4020(01)87185-4

Reference yield:

: 152934-35-5
(2S,3S,4S)-4-Benzyloxymethyl-2-methylhexane-1,3-diol

: 131967-58-3
(2S)-2-<(4S,5S)-5-Ethyl-2,2-dimethyl-1,3-dioxan-4-yl>propyl phenyl sulfone

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / pyridine / Ambient temperature

2: 100 percent / H₂ / 5percent Pd/C / ethyl acetate / 6 h / Ambient temperature

3: 98 percent / d-camphorsulfonic acid / benzene / 0.5 h / Ambient temperature

4: 96 percent / LiAlH₄ / diethyl ether / 1 h / 0 deg C to r.t.

5: 96 percent / pyridine / 2 h / Ambient temperature

6: 94 percent / NaI / acetone / 8 h / Heating

7: 93 percent / dimethylformamide / 6 h / 60 °C

With pyridine; lithium aluminium tetrahydride; (1S)-10-camphorsulfonic acid; hydrogen; sodium iodide; palladium on activated charcoal; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1016/S0040-4020(01)87185-4