6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester

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Chemical Name:6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester
CAS No.:176752-45-7
Molecular Formula:C₄₂H₄₇N₉O₈
Molecular Weight:805.891
Hs Code.:

6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester

Synonyms:6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester

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Chemical Property of 6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester

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Technology Process of 6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester

There total 7 articles about 6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 176752-44-6
6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-benzyloxycarbonyl-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester

: 176752-45-7
6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 0.5h; under 760 Torr;
DOI:10.1016/0968-0896(95)00183-2

Reference yield:

: 176752-42-4
(S)-2-Hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionic acid

: 176752-45-7
6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / KI, K₂CO₃ / dimethylformamide / 20 h / 23 °C

2: 26 percent / Et₃N, BOPCl / CH₂Cl₂ / 96 h / 25 °C

3: 79 percent / H₂ / 10percent Pd/C / methanol / 0.5 h / 25 °C / 760 Torr

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0968-0896(95)00183-2

Reference yield:

: 176752-41-3
(S)-2-Hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionic acid methyl ester

: 176752-45-7
6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / aq. LiOH / methanol; tetrahydrofuran / 1 h

2: 76 percent / KI, K₂CO₃ / dimethylformamide / 20 h / 23 °C

3: 26 percent / Et₃N, BOPCl / CH₂Cl₂ / 96 h / 25 °C

4: 79 percent / H₂ / 10percent Pd/C / methanol / 0.5 h / 25 °C / 760 Torr

With lithium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0968-0896(95)00183-2