2-azido-1-(4-phenoxybenzenesulfonamido)-3-[diethylphosphonoformamido]propane

Base Information

• Chemical Name: 2-azido-1-(4-phenoxybenzenesulfonamido)-3-[diethylphosphonoformamido]propane
• CAS No.: 1239876-43-7
• Molecular Formula: C₂₀H₂₆N₅O₇PS
• Molecular Weight: 511.495
• Mol file: 1239876-43-7.mol

Synonyms:2-azido-1-(4-phenoxybenzenesulfonamido)-3-[diethylphosphonoformamido]propane

Chemical Property of 2-azido-1-(4-phenoxybenzenesulfonamido)-3-[diethylphosphonoformamido]propane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-azido-1-(4-phenoxybenzenesulfonamido)-3-[diethylphosphonoformamido]propane

There total 1 articles about 2-azido-1-(4-phenoxybenzenesulfonamido)-3-[diethylphosphonoformamido]propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-azido-3-[diethylphosphonoformamido]propylamine (1239876-61-9) + 4-phenoxyphenylsulfonyl chloride (1623-92-3) → 2-azido-1-(4-phenoxybenzenesulfonamido)-3-[diethylphosphonoformamido]propane (1239876-43-7)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃;

Reference yield:

2-azido-1-(4-phenoxybenzenesulfonamido)-3-[diethylphosphonoformamido]propane (1239876-43-7) → C20H28N3O7PS

Guidance literature:

With pyridine; ammonium hydroxide; trimethylphosphane; In tetrahydrofuran; for 3h; Inert atmosphere;

Reference yield:

2-azido-1-(4-phenoxybenzenesulfonamido)-3-[diethylphosphonoformamido]propane (1239876-43-7) → JS-489 (1239876-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trimethylphosphane; ammonium hydroxide; pyridine / tetrahydrofuran / 3 h / Inert atmosphere

2.1: sodium hydrogencarbonate

2.2: 3 h / 50 °C

2.3: 0.5 h

With pyridine; ammonium hydroxide; sodium hydrogencarbonate; trimethylphosphane; In tetrahydrofuran;

DOI:10.1002/hc.21256

upstream raw materials:

2-azido-3-[diethylphosphonoformamido]propylamine

4-phenoxyphenylsulfonyl chloride

Downstream raw materials:

JS-489

2-Boc-amino-1-(4-phenoxybenzenesulfonamido)-3-[diethylphosphonoformamido]propane